New frontiers in hepatocellular carcinoma: Precision imaging for microvascular invasion prediction

doi:10.3748/wjg.v31.i8.102224

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Feb 28, 2025; 31(8): 102224
Published online Feb 28, 2025. doi: 10.3748/wjg.v31.i8.102224

Table 1 Microvascular invasion status prediction model performance[1]

Dataset	AUC (95%CI)	Sensitivity (%)	Specificity (%)	Accuracy (%)	Calibration (χ²)	P value
Training (n = 189)	0.841 (0.783-0.898)	88.8	64.4	79.4	8.327	0.402
Validation (n = 81)	0.768 (0.664-0.872)	80.9	61.8	72.8	12.804	0.119

AUC: Area under the curve. Citation: Xu ZL, Qian GX, Li YH, Lu JL, Wei MT, Bu XY, Ge YS, Cheng Y, Jia WD. Evaluating microvascular invasion in hepatitis B virus-related hepatocellular carcinoma based on contrast-enhanced computed tomography radiomics and clinicoradiological factors. World J Gastroenterol 2024; 30: 4801-4816.

Table 2 High-risk group status prediction model performance[1]

Dataset	AUC (95%CI)	Sensitivity (%)	Specificity (%)	Accuracy (%)	Calibration (χ²)	P value
Training (n = 189)	0.865 (0.797-0.934)	78.6	86.4	84.7	9.311	0.317
Validation (n = 81)	0.798 (0.676-0.919)	57.1	93.3	84.0	2.280	0.131

Table 3 Independent risk factors for microvascular invasion and high-risk group[1]

Prediction target	Risk factor	Odds ratio (95%CI)	P value
MVI status	Non-smooth tumor margin	2.655 (1.241-5.679)	0.012
	Absence of peritumoral hypointensity ring	5.360 (1.857-15.477)	0.002
	Radscore (ROI ^tumor-DP)	6.552 (3.364-12.761)	< 0.001
M2 status	AFP level	3.818 (1.380-10.563)	0.01
	Enhancing capsule	3.962 (1.628-9.643)	0.002
	AST level	3.760 (1.485-9.520)	0.005
	Radscore (ROI ^peri-AP)	5.967 (2.609-13.649)	< 0.001

MVI: Microvascular invasion; AUC: Area under the curve; AFP: Alpha-fetoprotein; AST: Aspartate aminotransferase; ROI ^tumor-DP: Region of interest of tumor from delayed phase; ROI ^peri-AP: Region of interest of peritumoral area from arterial phase. Citation: Xu ZL, Qian GX, Li YH, Lu JL, Wei MT, Bu XY, Ge YS, Cheng Y, Jia WD. Evaluating microvascular invasion in hepatitis B virus-related hepatocellular carcinoma based on contrast-enhanced computed tomography radiomics and clinicoradiological factors. World J Gastroenterol 2024; 30: 4801-4816.

Citation: Hao L, Zhang ZN, Han S, Li SS, Lin SX, Miao YD. New frontiers in hepatocellular carcinoma: Precision imaging for microvascular invasion prediction. World J Gastroenterol 2025; 31(8): 102224
URL: https://www.wjgnet.com/1007-9327/full/v31/i8/102224.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i8.102224