Primary extra-gastrointestinal stromal tumor of the gallbladder: A case report

Table 1 Summary of reported gallbladder gastrointestinal stromal tumor cases

Case	Ref.	Age (year)/sex	Clinical presentation	Tumor size (cm)	Pathology & IHC	Molecular detection	Treatment	Outcome
1	OrtizHidalgo et al[6], 2000	69/F	RUQ pain	2 × 2	CD117 (+), CD34 (+)	N/A	Laparoscopic cholecystectomy	N/A
2	MendozaMarin et al[7], 2002	34/F	RUQ pain	1.5	CD117 (+), VIM (+), CD34 (-), SMA (-)	N/A	Cholecystectomy	N/A
3	Park et al[8], 2004	72/F	RUQ pain	6 × 3	CD117 (+), VIM (+), CD34 (-), Desmin (-), SMA (-)	Mutations of the c-kit proto-oncogene were not found	Cholecystectomy	Liver metastasis 7 months after surgery, died after 9 months
4	Peerlinck et al[9], 2004	79/F	RUQ pain with fever	4	CD117 (+), Desmin (+), SMA (+)	N/A	Simple cholecystectomy	Progressive intra-abdominal disease 13 months after surgery, died after 15 months
5	Furihata et al[10], 2005	68/F	RUQ pain	6 × 5 × 4	CD117 (+), VIM (+), SMA (+), CD34 (-), Desmin (-)	Exon 9 of the c-kit gene (+)	Extended right hepatectomy with hepaticojejunostomy after portal vein embolization	No sign of metastasis or recurrence > 12 months postoperatively
6	Al-Daraji et al[11], 2009	48/F	Pain with fever	2 × 1	CD117 (+), CD34 (+)	N/A	Cholecystectomy	Died 5 days after surgery
7	Petrou et al[12], 2011	72/F	RUQ pain	7.5 × 3.5	CD117 (-), PDGFR (+)	Exon 18 of PDGFRA gene (+)	Cholecystectomy	N/A
8	Bolanaki et al[13], 2012	77/F	RUQ pain	7	CD117 (+), SMA (+), CD34 (-)	Failed to detect c-kit gene mutations in exons 9, 11, 13, and 17	Exploratory laparotomy	Died 10 days postoperatively
9	Kostov and Kobakov[14], 2012	41/F	N/A	N/A	CD117 (+), CD34 (-)	N/A	Cholecystectomy	N/A

F: Female; IHC: Immunohistochemistry; RUQ: Right upper quadrant abdominal pain; SMA: Smooth muscle actin; VIM: Vimentin; N/A: Not available.