From rescue to recovery: Reframing severe alcoholic hepatitis management through 90-day survival

Table 1 Key studies on interventions in severe alcoholic hepatitis with reported 90-day outcomes, as discussed in the systematic review by Quiñones-Calvo et al[4]

Ref.	Country	Study design	Sample size (n)	Intervention	Key 90-day outcome
Philips et al[3], 2017	India	Pilot RCT	26	Fecal microbiota transplantation	Significantly improved survival (HR = 0.528, 95%CI: 0.279-0.998, P = 0.044)
Thursz et al[5], 2015	Multinational	RCT	1103	Prednisolone vs pentoxifylline vs placebo	No significant survival benefit for prednisolone
Louvet et al[2], 2018	Multinational	Meta-analysis of individual patient data	1103	Corticosteroids	Reduced 28-day mortality, but no significant 90-day benefit (odds ratio = 1.02)
Thompson et al[8], 2018	Multinational	RCT	203	Extracorporeal cellular therapy	No significant improvement in survival
Arab et al[9], 2021	Worldwide	Observational cohort study	1338	Timing of corticosteroid administration	Early steroid use (by day 3) is associated with optimized 90-day survival
Szabo et al[6], 2022	United States	RCT	200	Anakinra + zinc + pentoxifylline vs pentoxifylline	No significant survival benefit (HR = 0.69, P = 0.28)
Louvet et al[7], 2023	France	RCT	284	Prophylactic antibiotics	No significant reduction in 90-day mortality

HR: Hazard ratio; RCT: Randomized controlled trial.