Guan RY, Wu JW, Yuan ZY, Liu ZY, Liu ZZ, Xiao ZC, Li JH, Huang CZ, Wang JJ, Yao XQ. Poorly controlled type II diabetes mellitus significantly enhances postoperative chemoresistance in patients with stage III colon cancer. World J Gastroenterol 2025; 31(3): 98688 [DOI: 10.3748/wjg.v31.i3.98688]
Corresponding Author of This Article
Xue-Qing Yao, MD, PhD, Professor, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, No. 106 Zhongshan Er Road, Guangzhou 510080, Guangdong Province, China. syyaoxueqing@scut.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Cohort Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Table 3 Comparison of disease-free survival, overall survival and chemoresistance rate in the non-diabetes mellitus, diabetes mellitus, well-controlled and poorly controlled groups, n (%)
Table 5 Univariate and multivariate cox regression analysis for chemoresistance rate
Variables
Univariate analysis
Multivariate analysis
HR (95%CI)
P value
HR (95%CI)
P value
Age (≥ 60/< 60), years
0.872 (0.663-1.025)
0.843
Gender (male/female)
1.004 (0.593-1.118)
0.703
BMI > 24 kg/m2 (present/absent)
1.931 (1.658-2.405)
0.007
History of DM (present/absent)
0.997 (0.556-1.200)
0.581
History of smoke (present/absent)
1.074 (0.665-1.209)
0.648
History of drinking(present/absent)
0.837 (0.425-1.102)
0.431
Hypertension (present/absent)
0.915 (0.503-1.220)
0.549
Cardiovascular disease (present/absent)
1.025 (0.694-1.280)
0.331
CEA (≥ 5/< 5), μg/mL
1.231 (0.994-1.398)
0.223
CA19-9 (≥ 37/< 37), ng/mL
1.096 (0.603-1.222)
0.387
T stage (4/3)
1.331 (0.967-1.438)
0.198
N stage (2/1)
1.669 (1.408-2.015)
0.019
1.594 (1.335-1.891)
0.041
Tumor location (RCC/LCC)
1.330 (0.894-1.505)
0.097
Tumor size (≥ 4.5/< 4.5), cm
1.205 (0.983-1.483)
0.105
Tumor differentiation (PD/MD)
1.606 (1.493-1.994)
0.013
1.499 (1.308-1.837)
0.028
Vascular invasion (present/absent)
1.999 (1.784-2.391)
< 0.001
1.803 (1.647-2.089)
0.009
Perineural invasion (present/absent)
1.347 (1.033-1.688)
0.124
FPG (≥ 7/< 7), mmol/L
2.558 (2.147-3.669)
< 0.001
2.214 (1.980-3.014)
0.005
HbA1c (≥ 7/< 7), %
2.867 (2.504-3.771)
< 0.001
2.449 (2.101-3.338)
0.009
Citation: Guan RY, Wu JW, Yuan ZY, Liu ZY, Liu ZZ, Xiao ZC, Li JH, Huang CZ, Wang JJ, Yao XQ. Poorly controlled type II diabetes mellitus significantly enhances postoperative chemoresistance in patients with stage III colon cancer. World J Gastroenterol 2025; 31(3): 98688