Imaging characteristics of hypervascular focal nodular hyperplasia-like lesions in patients with chronic alcoholic liver disease

Table 1 Summary of clinical findings

Patient No.	Age (years)	Sex	Background of liver failure	Child Pugh grade	AFP	PIVKA-II	Diagnosis	Lesion growth at imaging follow up
1	41	M	Alcoholic	A	6	23	FNB	N/A
2	33	F	Alcoholic	A	7	23	FNB	No growth
3	34	F	Alcoholic	B	4	10	FNB	Increased number
4	60	M	Alcoholic	B	9	20	FNB	No growth
5	58	M	Alcoholic	A	7	40	FNB	No growth
6	57	M	Alcoholic	B	6	19	FNB	N/A
7	53	M	Alcoholic	B	231	33	FNB	No growth
8	65	M	Alcoholic	A	10	18	FNB	Increased number
9	63	M	Alcoholic	A	6	12	FNB	No growth
10	48	F	Alcoholic	B	11	18	FNB	No growth
11	55	M	Alcoholic	B	5	16	FNB	N/A
12	70	M	Alcoholic	A	5	22	FNB	No growth
13	72	F	Alcoholic	A	4	15	FNB	No growth

¹Case 7 was only the patient with hepatocellular carcinomas.

PIVKA-II: Prothrombin induced by vitamin K deficiency or antagonist-II; FNB: Fine needle biopsy; AFP: Alpha-fetoprotein; N/A: Not available.

Table 2 Summary of tumor characteristics, dynamic patterns assessed using computed tomography and computed tomography hepatic arteriography, and pathological findings

Patient No.	No. of nodules	Size	Arterial enhancement pattern	Washout appearance	Modality	Central scar	Unpaired arteries and capillarization	Liver cell atypia	Scar-like fibrosis
1	2	15	Hyper	No	CECT/CTHA	-	+	-	-
2	1	15	Hyper	No	CECT/CTHA	-	+	-	-
3	> 4	10-15	Hyper	No	CECT/CTHA	-	+	-	-
4	> 4	10-30	Hyper	No	CECT/CTHA	+	+	-	+
5	1	10	Hyper	No	CECT	-	+	-	-
6	3	10-30	Hyper	No	CECT/CTHA	-	+	-/+	-
7	1	15	Hyper	No	CECT/CTHA	+	+	-	+
8	1	10	Hyper	No	CECT	-	+	-	-
9	1	10	Hyper	No	CECT	-	+	-	-
10	> 4	10-15	Hyper	No	CECT/CTHA	-	+	-	-
11	2	15	Hyper	No	CECT	-	+	-	-
12	1	20	Hyper	No	CECT	-	+	-	-
13	1	14	Hyper	No	CECT	+	+	-	-

CT: Computed tomography; CECT: Contrast-enhanced computed tomography; CTHA: Computed tomography hepatic arteriography.

Table 3 Summary of magnetic resonance imaging characteristics and findings

Patient No.	T1-weighted images	T2-weighted images	Central scar on magnetic resonance imaging	Chemical shift	Uptake pattern on the HBP	Uptake pattern on the SPIO
1	High	Iso-high	No	No	N/A	Homogenous
2	High	Iso-high	No	No	N/A	N/A
3	High	Low	No	No	N/A	Homogenous
4	Iso-high	Low	Yes	No	N/A	Homogenous
5	High	Iso-high	No	No	Ring	Homogenous
6	Low-high	Low	No	No	N/A	Homogenous
7	High	Iso	Yes	No	N/A	Homogenous
8	High	Low	No	No	Ring/hetero	Homogenous
9	High	Iso-high	No	No	N/A	Homogenous
10	High	Iso-high	No	No	Hetero	N/A
11	High	Low	No	No	Ring	N/A
12	Iso	Low	No	No	Hetero	N/A
13	Iso-high	Iso-high	Yes	No	Ring	N/A

SPIO: Superparamagnetic iron oxide; N/A: Not available.