Clinicopathological characteristics and prognostic outcomes of pregnancy-associated colorectal cancer: A 24-year experience

Table 1 Characteristics of pregnancy-associated colorectal cancer patients of different ages, n (%)

Characteristic	All pCRC, n	pCRC diagnosed < 35-year	pCRC diagnosed ≥ 35-year	P value
Total	43	32 (74.4)	11 (25.6)	< 0.001
Location of CRC				0.715
Proximal	10	7 (70)	3 (30)
Distal	33	25 (75.8)	8 (24.2)
Pathological stage				0.871
TNM I	2	1 (50)	1 (50)
TNM II	10	7 (70)	3 (30)
TNM III	18	15 (83.3)	3 (16.7)
TNM IV	13	9 (69.2)	4 (30.8)
Survival (months)				0.676
mean	52.3	52.6	51.5
Range	1-208	1-208

P value is for comparison between pregnancy-associated colorectal cancer diagnosed at age < 35 years and ≥ 35 years. pCRC: Pregnancy-associated colorectal cancer; CRC: Colorectal cancer; TNM: Tumor-node-metastasis.

Table 2 Strategies for treatment at different stages of pregnancy, n (%)

Treatment strategy	Pregnancy			Postpartum (within 12 months)	Total (n = 43)
	Early pregnancy (within 12 weeks)	Mid-pregnancy (13-27 weeks)	Late pregnancy (beyond 28 weeks)
Type of surgery
Palliative surgery	3	4	1	8	16 (37.2)
Radical surgery	1	2	2	16	21 (48.8)
No surgery	1	0	0	5	6 (14.0)
Chemotherapy
CapOx	2	4	2	15	23 (53.5)
FLOX4	3	1	1	9	14 (32.5)
No chemotherapy	0	1	0	5	6 (14.0)
Obstetric treatment
Abortion	5	3	0	\	8 (18.6)
Induced labor	0	1	1	\	2 (4.7)
Stillbirth	0	0	1	\	1 (2.3)
Cesarean section	0	2	1	17	20 (46.5)
Normal labor	0	0	0	12	12 (27.9)