Role of gut microbiota in Crohn’s disease pathogenesis: Insights from fecal microbiota transplantation in mouse model

Table 1 clinical data of 12 Crohn’s disease patients were collected in this study, n (%)

Patient characteristics	Quantity (percentage)
Sex
Female	3 (25.0)
Male	9 (75.0)
Age (years old)
≤ 16	0 (0.0)
17-40	8 (66.7)
> 40	4 (33.3)
Course of the disease (years)
< 1	1 (8.3)
1-5	7 (58.3)
> 5	4 (33.3)
Onset or recurrence of diseases
Onset	0 (0.0)
Recurrence	12 (100.0)
WBC count (× 109)
< 10.0	10 (83.3)
≥ 10.0	2 (16.7)
HGB (g/L)
< 100.0	3 (25.0)
≥ 100.0	9 (75.0)
ALB (g/L)
< 30.0	1 (8.3)
≥ 30.0	11 (91.7)
BMI (kg/m2)
< 18.5	4 (33.3)
≥ 18.5	8 (66.7)

This table succinctly presents the demographic and clinical characteristics of the 12 participants diagnosed with Crohn’s disease in the study. Among the cohort, 9 individuals (75.0%) were male, and 3 (25.0%) were female. The age distribution revealed that all participants were above 17 years old, with 8 patients (66.7%) falling between 17 and 40 years old, 4 patients (33.3%) aged over 40 years, and 1 patient (8.3%) having a disease duration within 1 year. In terms of disease duration, 7 patients (58.3%) had a duration between 1 and 5 years, while 4 patients (33.3%) had a disease duration exceeding 5 years. All 12 patients experienced disease recurrence. Preoperative test results indicated that 10 individuals (83.3%) exhibited white blood cell counts below 10.0 × 10⁹, and 2 individuals (16.7%) had counts reaching 10.0 × 10⁹. Hemoglobin levels below 100 g/L were observed in 3 patients (25.0%), with the remaining 9 patients (75.0%) reaching levels of 100 g/L. Serum albumin levels were below 30 g/L in only 1 patient (8.3%), while the remaining 11 patients (91.7%) achieved a serum albumin level of 30 g/L or higher. Preoperative measurements of height and weight demonstrated that 4 patients (33.3%) had a body mass index (BMI) value below 18.5 kg/m², and the remaining 8 patients (66.7%) had a BMI value equal to or exceeding 18.5 kg/m². WBC: White blood cell; HGB: Hemoglobin; ALB: Albumin; BMI: Body mass index.

Table 2 Clinical data of 5 Crohn’s disease patients who served as stool specimen donors, n (%)

Patient characteristics	Quantity (percentage)
Sex
Female	1 (20.0)
Male	4 (80.0)
Age (years old)
≤ 16	0 (0.0)
17-40	2 (40.0)
> 40	3 (60.0)
Course of the disease (years)
< 1	1 (20.0)
1-5	3 (60.0)
> 5	1 (20.0)
Onset or recurrence of diseases
Onset	0 (0.0)
Recurrence	5 (100.0)
WBC count (× 109)
< 10.0	2 (40.0)
≥ 10.0	3 (60.0)
HGB (g/L)
< 100.0	0 (0.0)
≥ 100.0	5 (100.0)
ALB (g/L)
< 30.0	3 (60.0)
≥ 30.0	2 (40.0)
BMI (kg/m2)
< 18.5	2 (40.0)
≥ 18.5	3 (60.0)

This table succinctly presents the demographic and clinical characteristics of the 5 stool specimen donor patients included in this study. Among them, 4 were male (80.0%) and 1 was female (20.0%). Age distribution showed that all patients were over 17 years old, 2 patients (40.0%) were between 17 and 40 years old, and the remaining 3 patients (60.0%) were over 40 years old. In terms of disease course, only 1 patient (20.0%) had a disease course within 1 year, 3 patients (60.0%) had a disease course between 1 and 5 years, and 1 patient (20.0%) had a disease course exceeding 5 years. All 12 patients had recurrent disease. Laboratory test results showed that the white blood cell (WBC) count of 2 people (40.0%) was lower than 10.0 × 10⁹, and the WBC count of 3 people (60.0%) reached 10.0 × 10⁹ and above. All 5 patients (100.0%) had hemoglobin levels of 100 g/L and above. Three patients (60.0%) had serum ALB levels below 30 g/L, and the remaining 2 patients (40.0%) had serum albumin levels of 30 g/L or higher. Height and weight measurements showed that 2 patients (40.0%) had a body mass index (BMI) value lower than 18.5 kg/m², and the remaining 3 patients (60.0%) had a BMI value equal to or exceeding 18.5 kg/m². WBC: White blood cell; HGB: Hemoglobin; ALB: Albumin; BMI: Body mass index.