Preclinical and clinical evidence of the association of colibactin-producing Escherichia coli with anxiety and depression in colon cancer

Table 1 Sociodemographic and clinical data stratified according to the presence of colibactin-producing Escherichia coli

	Total, n = 12	CoPEC+, n = 6	CoPEC-, n = 6	P value
Sociodemographic
Age (yr)	67 (63-85)	63 (57-65)	80.5 (79-82)	0.013
Sex, female	6 (50)	2 (33)	4 (67)	0.567
Educational level, more than 12 yr	2 (17)	1 (17)	1 (17)	1
Cohabiting couple	10 (83)	6 (100)	4 (67)	0.455
CRC
Follow-up since CRC surgery (yr)	4.9 (4.2-8.2)	6.5 (4.3-8.4)	4.7 (4.0-5.3)	0.513
Laparotomy	8 (67)	3 (50)	5 (83)	0.545
Left colon cancer	6 (50)	3 (50)	3 (50)	1
TNM CRC stage				0.545
1	2 (17)	2 (33)	-
2	6 (50)	3 (50)	3 (50)
3	3 (25)	1 (17)	2 (33)
4	1 (8)	-	1 (17)
Psychiatry
Personal past anxiety/major depressive disorders	7 (58)	6 (100)	1 (17)	0.015
Family psychiatric disorders	4 (33)	2 (33)	2 (33)	1
HDRS total score	5.5 (3.0-7.5)	6.5 (5.0-8.0)	4.5 (2.0-7.0)	0.422
HAMA total score	6.5 (3.5-10.5)	7.5 (6.0-10.0)	4.5 (3.0-11.0)	0.52
HAMA somatic score	0.5 (0.0-2.0)	1.0 (0.0-2.0)	0.0 (0.0-2.0)	0.388
HAMA psychic score	5 (2.5-8.5)	5.5 (4.0-8.0)	4.5 (1.0-11.0)	0.936

The data are reported as medians (interquartile ranges) or n (%). CoPEC: Colibactin-producing Escherichia coli; CRC: Colorectal cancer; HAMA: Hamilton Anxiety Rating Scale; HDRS: Hamilton Depression Rating Scale.