Effects of tetrandrine on gastric mucosa and liver in portal hypertensive rats

Table 1 Portal venous pressure (PVP), gastric mucosal prostaglandin E2 (PGE2) content, gastric mucosal blood flow (GMBF) and gastric adherent mucus (GAM) (x- ± s)

Groups	PVP (kPa)	PGE2 (pg/mg)	GMBF (mL·h·kg)	GAM (mg)
PHT	1.89 ± 0.18d	104.65 ± 12.97d	6.61 ± 2.82c	2.24 ± 0.26d
Propranolol	1.45 ± 0.12b	129.98 ± 14.31b	10.54 ± 3.63a	2.98 ± 0.21b
Tetrandrine	1.43 ± 0.13b	138.59 ± 12.68b	11.80 ± 3.47a	3.01 ± 0.15b
Normal	1.24 ± 0.10bc	162.03 ± 13.84bd	18.86 ± 4.37bd	3.25 ± 0.16b

^aP < 0.05,

^bP < 0.01, vs portal hypertensive (PHT) controls group;

^cP < 0.05,

^dP < 0.01, vs propranolol group.

Table 2 Alanine aminotransferase (ALT), alkaline phosphatas (ALP) and serum total bilirubin (STB) (x- ± s)

Groups	ALT (king U)	ALP (µmol·s-1/L)	STB (µmol/L)
PHT	189.33 ± 41.21	0.31 ± 0.06d	11.12 ± 2.39
Propranolol	209.34 ± 36.91	0.46 ± 0.05b	11.63 ± 3.01
Tetrandrine	47.67 ± 25.90bd	0.22 ± 0.04ad	4.75 ± 0.76bd
Normal	36.42 ± 21.53bd	0.21 ± 0.04ad	4.96 ± 0.91bd

^aP < 0.05,

^bP < 0.01 vs portal hypertensive (PHT) controls group;

^dP < 0.01 vs propranolol group.

Table 3 The liver fibrosis degree

Groups	Grade 4+++	Grade 3++	Grade 2+	Grade 1-
PHT	6	2	0	0
Propranolol	4	3	1	0
Tetrandrineac	0	4	2	2
Normalbd	0	0	1	7

^aP < 0.05,

^bP < 0.01, vs portal hypertensive (PHT) controls group;

^cP < 0.05,

^dP < 0.01, vs propranolol group.