A prospective study of vertical transmission of hepatitis C virus

Table 1 Sequences of hepatitis C virus test and genotype primers

Purpose	Code	Position	n	Direction	Sequences (5'-)	Target geno bp type
Test	F1	5′NC	153	Sense	GGCGACACTCCACCATGAATC
	R1		154	Antisense	GGTGCACGGTCTACGAGACCT324
	F3		204	Sense	ATGAGTGTCGTGCAGCCTCCA111
	R3		203	Antisense	GTTTATCCAAGAAAGGACCCG
Type	A	C	256	Sense	CGCGCGACTAGGAAGACTTC
	B		186	Antisense	ATGTACCCCATGAGGTGGGC272
	C		104	Sense	AGGAAGACTTCCGAGCGGTC
	D1		132	Antisense	TGCCTTGGGGATAGGCTGAC57	I
	D2		133	Antisense	GAGCCATCCTGCCCTCCCCA144	II
	D3		134	Antisense	CCAAGAGGGACGGGAACCTC174	III
	D4		135	Antisense	ACCCTCGTTTCCGTACAGAG123	IV

Table 3 Serological markers and clinical feature of infants

Code	Mothers infected with hepatitis C virus during pregnancy			Months from conception to disease onset	Age (months) of infants
					1			3			6			9			12			18			24			36
	C	R	A		C	R	A	C	R	A	C	R	A	C	R	A	C	R	A	C	R	A	C	R	A	C	R	A
1	+	+	+1	3	+	+	+1	+	+	-	+	+	-	+	+	-	+	+	-	+	+	-	+	+	-	+	+	-
1-2	+	-	-	32	+	+	-	+	+	-	+	+	-	+	-	-	-	-	-
2	+	+	+1	37	+	+	-	+	+	-	+	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
2-2	+	+	-	54	+	+	-	+	+	-	-	-	-	-	-	-	-	-	-
-	+	+	-	-	-	-	-	-	-	-	-	-
4	+	+	+1	1	+	+	-	+	+	-	+	+	-	+	+	-	+	+	-	+	+	-	-	+	-	-	+	-
5	+	+	+1	7	+	+	-	+	+	-	+	+	-	N	N	N	-	+	-	-	+	-	-	-	-	-	-	-
6	+	+	-	12	+	+	+	+	+	+	+	+	-	+	+	-	-	+	+	-	+	-	-	-	-	-	-	-
7	+	+	-	17	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
8	+	+	-	30	+	+	-	N	N	N	+	+	-	N	N	N	-	-	-
9	+	+	-	25	+	+	-	+	+	-	+	+	-	N	N	N	-	-	-
10	+	+	+	23	+	+	-	+	+	-	+	+	-	-	-	-
11	+	+	-	37	-	-	-	-	-	-	-	-	-	-	-	-
12	+	+	-1	12	+	+	+	N	N	N	N	N	N	-	-	-	-	-	-
13	+	-	-	29	+	+	-	N	N	N	N	N	N	-	-	-	-	-	-

C: Anti Hepatitis C virus; R: Hepatitis C virus RNA; A: Alanine aminotransferase; N: ND;

¹: Symptom and sign of hepatitis.

Table 4 Serological profiles of infants during follow-up

Month(s)	Number	Anti hepatitis C virus antibody +		hepatitis C virus RNA +
		Number	%	Number	%
1	12 (13)	12 (13)	100.0 (100.0)	12 (13)	100.0 (100.0)
3	9 (11)	9 (11)	100.0 (100.0)	9 (11)	100.0 (100.0)
6	10 (11)	9 (10)	90.0 (90.9)	9 (10)	90.0 (90.9)
9	11 (13)	6 (6)	54.5 (46.2)	5 (5)	45.5 (38.5)
12	12 (13)	3 (3)	25.0 (23.1)	5 (5)	41.7 (38.5)
18	6 (13)	2 (2)	33.3 (15.4)	4 (4)	66.7 (30.8)
24	6 (13)	1 (1)	16.7 (7.7)	2 (2)	33.4 (15.4)
36	6 (13)	1 (1)	16.7 (7.7)	2 (2)	33.3 (15.4)