Causal associations between inflammatory bowel disease and anxiety: A bidirectional Mendelian randomization study

Table 1 Causal estimates between ulcerative colitis or Crohn’s disease and anxiety by Mendelian randomization analysis

Exposure	Outcome	SNPs (n)	IVW			Weighted median		MR Egger
			OR [95%CI]	P value	Cochran’s Q P value	OR [95% CI]	P value	OR [95%CI]	P value	Intercept P value
UC	Anxiety	34	1.071 (1.009-1.135)	0.023	0.709	1.064 (0.981-1.154)	0.131	1.138 (0.945-1.371)	0.182	0.501
CD	Anxiety	46	1.005 (0.960-1.052)	0.825	0.713	1.027 (0.960-1.100)	0.435	1.023 (0.914-1.145)	0.689	0.734
Anxiety	UC	21	0.920 (0.779-1.086)	0.325	0.858	0.820 (0.654-1.027)	0.085	0.807 (0.594-1.096)	0.187	0.333
Anxiety	CD	21	1.012 (0.851-1.204)	0.892	0.808	0.998 (0.771-1.291)	0.989	1.016 (0.744-1.388)	0.919	0.974

MR: Mendelian randomization; UC: Ulcerative colitis; CD: Crohn’s disease; IVW: Inverse-variance weighted; SNPs: Single-nucleotide polymorphisms; OR: Odds ratio; CI: Confidence intervals.