Colorectal motility patterns and psychiatric traits in functional constipation and constipation-predominant irritable bowel syndrome: A study from China

Table 1 Comparison of baseline characteristics between constipation-predominant irritable bowel syndrome and functional constipation patients

Variable	IBS-C	FC	P value
Age (yr)	42.32 ± 14.41	43.95 ± 18.04	> 0.05
Sex			> 0.05
Male	17	8
Female	84	33
Stool frequency			> 0.05
> 6 d	23	6
< 6 d	72	27
Feeling of incomplete emptying			> 0.05
Yes	76	26
No	18	13
Sensation that stool cannot be passed			> 0.05
Yes	54	16
No	16	11
Feeling of defecation urgency			> 0.05
Yes	39	7
No	56	24
Straining during a bowel movement			> 0.05
Yes	91	28
No	5	5

The values are expressed as numbers (n) or mean ± SD. IBS-C: Constipation-predominant irritable bowel syndrome; FC: Functional constipation.

Table 2 Comparison of psychiatric and colorectal motility characteristics between constipation-predominant irritable bowel syndrome and functional constipation patients

Variable	IBS-C	FC	P value
ARM
Dyssynergic patterns			> 0.05
I	19	12
II	18	8
III	5	1
IV	14	10
Normal	6	1
Unclassified	7	1
Anorectal sensation thresholds
First constant sensation			> 0.05
Low	2	1
High	38	14
Normal	25	10
Desire to defecate			> 0.05
Low	30	10
High	4	1
Normal	22	10
Sustained urgency			> 0.05
Low	30	12
High	4	1
Normal	29	14
CTT			< 0.05
STC	37	7
RS accumulation	27	22
Normal	37	15
Psychiatric characteristics
Scores			> 0.05
HAMA	11.71 ± 9.48	12.00 ± 9.15
HAMD	11.51 ± 8.61	9.41 ± 0.33
Anxiety			> 0.05
No	34	13
Possible	24	7
Yes	35	13
Depression			< 0.05
No	31	19
Possible	46	9
Yes	15	5

The values are expressed as numbers (n) or mean ± SD. ARM: Anorectal manometry; CTT: Colonic transmit test; IBS-C: Constipation-predominant irritable bowel syndrome; FC: Functional constipation; HAMA: Hamilton anxiety rating scale; HAMD: Hamilton Depression Rating Scale.

Table 3 Comparison between psychiatric and colorectal motility characteristics in constipation-predominant irritable bowel syndrome and functional constipation patients

Variable	IBS-C				FC
	Anxiety	Without anxiety	Depression	Without depression	Anxiety	Without anxiety	Depression	Without depression
STC	21	16	25	12	4	1	3	2
NTC	24	6	21	9	8	3	5	6
First sensation
High	26	8	21	11	10	1	5	6
Normal	14	9	11	12	4	5	4	5
Desire toa
Low	19	11	13	16	6	4	6	4
Normal	16	6	15	6	8	2	4	6
High	4	0	3	1	1	0	0	1
Urgency
Low	15	12	14	12	4	4	5	3
Normal	21	5	15	10	10	2	5	7
High	3	0	2	1	1	0	0	1

^aχ² = 4.054, P < 0.05 for the association of the threshold of desire to defecate and depression in constipation-predominant irritable bowel syndrome patients.

The values are expressed as numbers (n). STC: Slow transmit constipation; NTC: Normal transmit constipation; IBS-C: Constipation-predominant irritable bowel syndrome; FC: Functional constipation.

Table 4 Correlations of psychiatric characteristics and anorectal sensation thresholds in constipation-predominant irritable bowel syndrome and functional constipation patients

		Thresholds of first sensation				Thresholds of desire to defecate					Thresholds of urgency
		High	Normal	r	P value	Low	Normal	High	r	P value	Low	Normal	High	r	P value
IBS-C	Anxiety degree			0.414	< 0.05				0.404	< 0.05				0.407	< 0.05
	Depression degrees			0.803	> 0.05				0.019	> 0.05				-0.018	> 0.05
FC	Anxiety degree			0.241	> 0.05				0.111	> 0.05				0.242	> 0.05
	Depression degrees			-0.098	> 0.05				-0.166	> 0.05				-0.233	> 0.05

IBS-C: Constipation-predominant irritable bowel syndrome; FC: Functional constipation.