F-box only protein 2 exacerbates non-alcoholic fatty liver disease by targeting the hydroxyl CoA dehydrogenase alpha subunit

Table 1 Clinical information of normal controls and patients with non-alcoholic fatty liver disease

	Normal (n = 10)	NAFLD (n = 10)	t value	P value
Gender			-	-
Male, %	4 (40)	4 (40)
Female, %	6 (60)	6 (60)
Age, yr	33.30 ± 2.83	32.40 ± 7.09	0.373	0.714
Height, cm	169.10 ± 7.84	169.80 ± 10.38	0.170	0.867
Body weight, kg	70.95 ± 16.48	118.04 ± 28.87	4.480	< 0.001
Body mass index, kg/m2	24.51 ± 4.02	40.41 ± 5.41	7.454	< 0.001
Waist circumference, cm	90.80 ± 11.33	128.5 ± 3.98	9.928	< 0.001
Systolic BP, mmHg	126.40 ± 6.33	134.80 ± 10.23	2.208	0.04
ALT, U/L	12.00 ± 6.77	69.00 ± 63.20	2.836	0.011
AST, U/L	15.40 ± 3.17	46.70 ± 29.74	3.309	0.004
GLDH, U/L	1.94 ± 1.22	7.74 ± 4.98	3.580	0.002
T-Cho, mmol/L	3.97 ± 0.52	4.47 ± 0.77	1.700	0.106
HDL, mmol/L	1.31 ± 0.20	0.97 ± 0.14	4.486	< 0.001
LDL, mmol/L	2.19 ± 0.37	2.83 ± 0.62	2.824	0.011
sdLDL, mmol/L	0.34 ± 0.14	1.11 ± 0.51	4.580	< 0.001
TG, mmol/L	0.62 ± 0.20	2.05 ± 0.67	6.483	< 0.001
NEFA, µmol/L	44.41 ± 29.72	55.20 ± 15.05	1.024	0.319
FPG, mmol/L	4.82 ± 0.33	4.81 ± 1.09	0.014	0.989
NASH score	0	5.10 ± 1.30	-	-

Data are presented as the mean ± SD. P < 0.05 was considered statistically significant. ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; BP: Blood pressure; FPG: Fasting plasma glucose; HDL: High-density lipoprotein; LDL: Low-density lipoprotein; NEFA: Nonesterified fatty acid; NAFLD: Non-alcoholic fatty liver disease; NASH: Non-alcoholic steatohepatitis; sdLDL: Small and dense low-density lipoproteins; TG: Triglycerides; T-Cho: Total cholesterol.