Screening and interventions to prevent nonalcoholic fatty liver disease/nonalcoholic steatohepatitis-associated hepatocellular carcinoma

Table 1 Summary of lifestyle and pharmacological intervention with potential preventive effects against developing nonalcoholic fatty liver disease/nonalcoholic steatohepatitis-associated hepatocellular carcinoma

Interventions with potential protective effects
Lifestyle interventions	Weight loss
	Dietary changes
	Adherence to healthy eating patterns: Mediterranean diet, traditional Cantonese dietary pattern; Chinese Healthy Eating Index
	Reduced intake of: Saturated fats, sugar-sweetened beverages, alcohol
	Increased intake of: Vegetables, coffee; possibly fiber, white meat and fish, omega-3 polyunsaturated fatty acids, vitamin E
	Physical exercise
	Smoking cessation
Pharmacological interventions	Metformin
	Statins
	Aspirin
	Possibly also: Pioglitazone, GLP-1 RA, vitamin E (in nondiabetic individuals?), obeticholic acid

GLP-1 RA: Glucagon-like peptide-1 receptor agonists.