Risk factors predict microscopic extranodal tumor deposits in advanced stage III colon cancer patients

Table 1 Baseline characteristics of N1c group and non-N1c group, n (%)

Item	N1c	Non-N1c	P value
Sample size (n)	19	136
Gender			0.08
Male	13 (68.4)	64 (47.1)
Female	6 (31.6)	72 (52.9)
Mean age (yr)	66.79	65.17	0.09
BMI (kg/m2)	22.77	23.41	0.15
Habit of smoking	8 (42.1)	46 (33.8)	0.48
Habit of alcoholic drinking	4 (21.1)	13 (9.6)	0.13
Hypertension	6 (31.6)	46 (33.8)	0.85
Diabetes mellitus	4 (21.1)	29 (21.3)	0.98
Neutrophil to Lymphocyte ratio	4.33	4.62	0.42
CEA (mg/dL)	12.83	18.23	0.62
CA 19-9 (mg/dL)	23.61	29.14	0.20
Tumor characteristics
Location			0.27
Right colon	6 (9)	61 (91)
Left colon	13 (14.8)	75 (85.2)
T stage			0.90
T1	1 (5.3)	5 (3.7)
T2	1 (5.3)	12 (8.8)
T3	16 (84.2)	110 (80.9)
T4a	0 (0)	4 (2.9)
T4b	1 (5.3)	5 (3.7)
Mean tumor size (cm)	4.24	4.8	0.98
Tumor type			0.26
Polypoid	8 (42.1)	76 (55.9)
Ulcerative	11 (57.9)	60 (44.1)
Tumor grade			0.62
Well	0	5 (100)
Moderate	16 (13.3)	104 (86.7)
Poor	3 (10.0)	27 (90.0)
EGFR	17 (89.5)	117 (86.0)	0.68
Lymphovascular invasion	3 (15.8)	53 (39.0)	0.049

95%CI: 95% confidence interval; BMI: Body mass index; NLR: Neutrophil to lymphocyte ratio; CEA: Carcinoembryonic antigen; CA 19-9: Carbohydrate antigen 19-9.

Table 2 N1c group vs non-N1c group by multivariable cox regression

Item	Multivariable logistic regression
	Exp (B)	95%CI	P value
Gender
Female	Reference
Male	4.62	(1.17-18.33)	0.030
Age	1.03	(0.99-1.08)	0.190
BMI	0.84	(0.68-1.04)	0.110
Habit of smoking	0.92	(0.27-3.07)	0.890
Habit of alcoholic drinking	1.41	(0.29-6.81)	0.670
Hypertension	0.87	(0.21-3.85)	0.850
Diabetes mellitus	0.69	(0.19-2.52)	0.570
Neutrophil to Lymphocyte ratio	1.03	(0.92-1.15)	0.660
CEA	1.00	(1.00-1.01)	0.770
CA 19-9	1.02	(0.99-1.04)	0.200
Tumor characteristics
Location
Right colon	Reference
Left colon	1.67	(0.45-6.21)	0.440
T stage
Tumor size	0.99	(0.96-1.02)	0.550
Tumor type
Polypoid	Reference
Ulcerative	1.75	(0.62-4.92)	0.290
Tumor grade	0.51	(0.12-2.21)	0.370
EGFR	1.05	(0.20-5.48)	0.950
Lymphovascular invasion	6.16	(1.24-30.10)	0.027

95%CI: 95% confidence interval; BMI: Body mass index; NLR: Neutrophil to lymphocyte ratio; CEA: Carcinoembryonic antigen; CA 19-9: Carbohydrate antigen 19-9.