Atrophic gastritis and gastric cancer tissue miRNome analysis reveals hsa-miR-129-1 and hsa-miR-196a as potential early diagnostic biomarkers

Table 1 Demographic characteristics of profiling and validation cohorts

		Profiling cohort (n = 60)			Validation cohort (n = 65)
		CON (n = 21)	AG (n = 19)	GC (n = 20)	CON (n = 11)	AG (n = 30)	GC (n = 24)
Age	Mean ± SD	58.29 ± 15.52	69.21 ± 8.78	64.95 ± 10.89	42.27 ± 12.89	68.01 ± 11.81	68.33 ± 11.27
Gender (n)	Male	5	3	15	5	9	18
	Female	16	16	5	6	21	6
Helicobacter pylori infection (n)	Negative	12	10	8	-	17	9
	Positive	9	9	9	-	10	4
	Unknown	-	-	3	11	3	11
Differentiation grade (n)	G1	-	-	4	-	-	-
	G2	-	-	4	-	-	12
	G3	-	-	12	-	-	12
Lauren classification (n)	Diffuse	-	-	10	-	-	8
	Intestinal	-	-	10	-	-	13
	Mixed	-	-	-	-	-	2
	Unknown	-	-	-	-	-	1
T (n)	T1	-	-	6	-	-	3
	T2	-	-	2	-	-	5
	T3	-	-	8	-	-	9
	T4	-	-	4	-	-	6
	Unknown	-	-	-	-	-	1
N (n)	N0	-	-	10	-	-	6
	N1	-	-	2	-	-	5
	N2	-	-	3	-	-	4
	N3	-	-	5	-	-	8
	Unknown	-	-	-	-	-	1
M (n)	M0	-	-	7	-	-	14
	M1	-	-	2	-	-	9
	Unknown	-	-	11	-	-	1

SD: Standard deviation; CON: Control; AG: Atrophic gastritis; GC: Gastric cancer.