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©The Author(s) 2022.
World J Gastroenterol. Dec 28, 2022; 28(48): 6900-6908
Published online Dec 28, 2022. doi: 10.3748/wjg.v28.i48.6900
Published online Dec 28, 2022. doi: 10.3748/wjg.v28.i48.6900
Classification | Code | Diagnosis | Subtype | Subtype 2 |
JGCA[16] | Gastric adenoma | Intestinal type | ||
Gastric type | Pyloric gland type | |||
Foveolar type | ||||
WHO 2019[13] | 8148/0 | Glandular intraepithelial neoplasia, low grade | ||
8148/2 | Glandular intraepithelial neoplasia, high grade | |||
8213/0 | Serrated dysplasia, low grade | |||
8213/2 | Serrated dysplasia, high grade | Intestinal-type dysplasia | ||
Foveolar-type (gastric type) dysplasia | ||||
Gastric pit/crypt dysplasia | ||||
8144/0 | Intestinal-type adenoma, low grade | |||
8114/2 | Intestinal-type adenoma, low grade | Sporadic intestinal-type gastric adenoma | ||
Syndromic intestinal-type gastric adenoma | ||||
8210/0 | Adenomatous polyp, low-grade dysplasia | |||
8210/2 | Adenomatous polyp, high-grade dysplasia | |||
Vienna[14] | 3 | Non-invasive low-grade neoplasia | Low-grade adenoma/dysplasia | |
4 | Non-invasive high-grade neoplasia | |||
4.1 | High-grade adenoma/dysplasia | |||
4.2 | Non-invasive carcinoma (carcinoma in situ) | |||
4.3 | Suspicion of invasive carcinoma | |||
5 | Invasive neoplasia | |||
5.1 | Intramucosal carcinoma | |||
5.2 | Submucosal carcinoma or beyond | |||
Revised Vienna[15] | 3 | Mucosal low-grade neoplasia | Low-grade adenoma/dysplasia | |
4 | Mucosal high-grade neoplasia | |||
4.1 | High-grade adenoma/dysplasia | |||
4.2 | Non-invasive carcinoma (carcinoma in situ) | |||
4.3 | Suspicious for invasive carcinoma | |||
4.4 | Intramucosal carcinoma | |||
5 | Submucosal invasion by carcinoma |
Type | Chromosomal instability | EBV | Microsatellite instability | Genomically stable |
Percentage | 50% | 9% | 21% | 20% |
Profile of patients | Male prevalence | Elderly age | Younger age | |
Location | GEJ, cardia | Corpus or fundus | Antrum | Distal location |
Lauren type | Intestinal | Intestinal | Poorly cohesive | |
Other pathological feature | DNA aneuploidy | Carcinoma with lymphoid stroma | ||
Prognosis | Favorable | Worst | ||
Genetic features | TP53 mutation | Extensive DNA promoter methylation | MLH1 promoter hypermethylation | Low copy number alterations and mutational burden |
Amplification of TKR | CDKN2A promoter hypermethylation | High mutational burden | ARID1, RHOA, CDH1 mutations | |
PIK3CA, ARID1A, BCOR mutations | CLDN18-ARHGAP26 fusion in 15% |
- Citation: Kinami S, Yamada S, Takamura H. Confusion and prospects for carcinogenesis of gastric adenoma and dysplasia: What is the correct answer currently? World J Gastroenterol 2022; 28(48): 6900-6908
- URL: https://www.wjgnet.com/1007-9327/full/v28/i48/6900.htm
- DOI: https://dx.doi.org/10.3748/wjg.v28.i48.6900