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Copyright ©The Author(s) 2022.
World J Gastroenterol. Nov 21, 2022; 28(43): 6099-6108
Published online Nov 21, 2022. doi: 10.3748/wjg.v28.i43.6099
Table 1 Effects of current strategies on nonalcoholic fatty liver disease with sleep apnea syndrome
Category
Effects
Ref.
Lifestyle measuresMediterranean dietInhibition of inflammation and oxidative stress that occur in OSAHS and improvement of upper-airway neuromuscular control and muscle force-generating capacity[51]
Dietary behavior change, moderate-intensity aerobic exercise, sleep hygiene, and tobacco and alcohol avoidanceIncreases in adherence to the Mediterranean diet[52]
Reduced AHI and oxygen desaturation index
Increased sleep quality
Decease of body weight, fat mass, visceral adipose tissue, and neck, chest, and waist circumferences
Aerobic exercise trainingReduced body weight improved blood circulation, better sleep quality and less daytime sleepiness[56-58]
MedicationsPhentermine plus extended-release topiramateSignificant improvements in overnight oxygen saturation and reduction in blood pressure[42]
Liraglutide and semaglutideHistological resolution of NASH and improved metabolic control[43-48]
Decreased AHI, body weight, SBP and HbA1c
MBSVSG or other MBSReduced AHI[62-64]
VSG100% remission rate in patients with OSAHS who also underwent hiatal hernia repair[65]
MBSImproved sleep apnea and nocturnal hypoxia, as well as liver steatosis and fibrosis[66]