Basic Study
Copyright ©The Author(s) 2022.
World J Gastroenterol. Jan 21, 2022; 28(3): 348-364
Published online Jan 21, 2022. doi: 10.3748/wjg.v28.i3.348
Table 1 Activity of lipid peroxidation levels, antioxidant enzyme superoxide dismutase, and nitric oxide levels in the experimental groups
Groups
TBARS
SOD
NO2/NO3
CO0.29 ± 0.012.62 ± 0.111.69 ± 0.08
CO + MLT0.34 ± 0.022.43 ± 0.051.76 ± 0.09
BDL3.43 ± 0.08a0.61 ± 0.05a5.53 ± 0.30a
BDL + MLT0.46 ± 0.01b2.30 ± 0.07b2.48 ± 0.36b
Table 2 Comet assay in liver tissue of rats that underwent bile duct ligation treated or not with melatonin
Group
Damage index
Damage frequency
CO77.4 ± 8.672.2 ± 7.3
CO + MLT72.6 ± 16.267.8 ± 14.8
BDL295.5 ± 34.8a 100.0 ± 0.0c
BDL + MLT171.6 ± 32.9b91.6 ± 9.5
Table 3 Micronucleus test in the bone marrow of the rats that underwent bile duct ligation, treated or not with melatonin
Groups
MNPCE1 in 2000 PCE
Ratio PCE/NCE2
CO4.0 ± 1.51.1 ± 0.2
CO + MLT3.3 ± 1.01.1 ± 0.4
BDL7.8 ± 1.3a1.0 ± 0.6
BDL + MLT6.8 ± 1.90.9 ± 0.5