Prednisolone induced pneumatosis coli and pneumoperitoneum

Table 1 Modified Naranjo score-pneumatosis intestinalis specific score

Question	Yes/No/Do not know	Score
Are there previous conclusive reports on this reaction?	Yes	1
Did the adverse event appear after the suspected drug was administered?	Yes	2
Did the adverse reaction improve when the drug was discontinued, or a specific antagonist was administered?	Yes	1
Are there alternative causes (other than the drug) that could on their own have caused the reaction?	No	0
Was the reaction more severe when the dose was increased or less severe when the dose was decreased?	Yes	1
Did the patient have a similar reaction to the same or similar drugs in any previous exposure?	No	0
Did any objective evidence confirm the adverse event?	Yes	1
Were there any symptoms or signs of abdominal pathology? (instead of isolation of drug in toxic concentrations in body fluid)	No	1
Were the serum inflammatory markers normal? (instead of drug rechallenge to evaluate for reoccurrence of symptoms)	Yes	1
Did imaging studies rule out hollow viscus perforation or inflammatory abdominal organ pathology? (instead of response to placebo administration)	Yes	1
Total score		9 (definite)

Table 2 Interpretation of scores

Total score	Interpretation of scores
≥ 9	Definite
5 to 8	Probable
1 to 4	Possible
≤ 0	Doubtful