Hepatocellular carcinoma, hepatitis C virus infection and miRNA involvement: Perspectives for new therapeutic approaches

Table 1 List of registered trials that use miRNAs as diagnostic and/or prognostic tool for hepatocellular carcinoma

Study title	Phase	Status	NCT number
MicroRNAs as diagnostic biomarkers in hepatocellular carcinoma among Somali patients	NA	Unknown	NCT03227510
Prospective cohort study of changes in circulatory microRNA of resected hepatocellular carcinoma	NA	Recruiting	NCT05148572
Clinical significance of hepatic and circulating microRNAs miR-221 and miR-222 in hepatocellular carcinoma	NA	Unknown	NCT02928627
Study of microRNAs as a diagnostic tool for HCV-related hepatocellular carcinoma	NA	Unknown	NCT03429530
Impact of IL-28B rs12979860 and rs4803217 gene polymorphisms associated with miRNAs deregulation on HCV-related hepatocellular carcinoma	NA	Unknown	NCT02507882
MiRNA as a diagnostic and prognostic biomarker of hepatocellular carcinoma	NA	Not yet recruiting	NCT02448056
Early Detection of Hepatocellular Carcinoma in a High-risk Prospective Cohort (ELEGANCE)	NA	Recruiting	NCT04965259
Blood sample collection for experimental blood test to track liver cancer	NA	Recruiting	NCT04720430
Different genetic features associated with hepatic carcinogenesis	NA	Unknown	NCT01247506
Genetic profiling of liver cancer in patients undergoing liver transplantation	NA	Active, not recruiting	NCT02412579
A study of individualized radiotherapy based on a prediction model of lymph node metastasis in hepatocellular carcinoma	NA	Unknown	NCT03416803
Fingerprint characterization of sorafenib treated HCC	NA	Unknown	NCT03958669
Risk of HCC in cirrhotic patients post DAAs treatment	NA	Unknown	NCT03414554
Risk of hepatocellular carcinoma in patient with liver cirrhosis	NA	Unknown	NCT03083002
Axitinib for the treatment of advanced hepatocellular carcinoma	2	Completed	NCT01210495
The phase III study of icaritin versus sorafenib in PD-L1 positive advanced hepatocellular carcinoma subjects	3	Recruiting	NCT03236649
The phase III study of icaritin versus HUACHANSU PIAN in hepatocellular carcinoma subjects	3	Recruiting	NCT03236636
A study of rSIFN-co in subjects with advanced solid tumors	1	Completed	NCT02387307
Stereotactic body radiation therapy and transarterial chemoembolization in treating patients with liver cancer that cannot be removed by surgery	1	Completed	NCT02507765
Nal-IRI with 5-fluorouracil (5-FU) and leucovorin or gemcitabine plus cisplatin in advanced biliary-tract cancer	2	Active, not recruiting	NCT03044587

NA: Not applicable.