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Copyright ©The Author(s) 2021.
World J Gastroenterol. Mar 7, 2021; 27(9): 782-793
Published online Mar 7, 2021. doi: 10.3748/wjg.v27.i9.782
Table 1 Characteristics of liver injury in patients with coronavirus disease 2019 and hepatitis B virus coinfection
Reference
Number of analyzed cases
HBV cases, n (%)
HBV status
Anti-HBV therapy, n (%)
ALT (U/L)1
AST (U/L)1
TBil (μmol/L)1
GGT (U/L)1
Note
Zou et al[21]105105 (100)HBsAg(+), 94% HBeAg (–)13 (12.38); entecavir (9, 8.75); tenofovir (3, 2.86); lamivudine/defovir (1, 0.95)23 (15-33)28 (19-43)8.3 (6.6-12.8)24 (16-36)Four patients developed ACLF and liver injury was associated with disease severity and worse prognosis
Chen et al[22]32620 (6.1)HBsAg(+); HBeAg(–); HBV DNA < 100 IU/mLNA28.00 (16.25-42.25)27.50 (22.00-42.25)10.55 (6.83-15.73)23.50 (15.50-35.25)No differences in the level of liver function (HBV vs non-HBV)
Liu et al[23]34721 (6.4)HBsAg(+); 95% HBeAg(–)1 (4.8) tenofovir30.40 (22.00-36.85)34.15 (27.00-39.5812.60 (10.50-16.43)28.50 (17.25-43.42)Three patients had HBV reactivation
Li et al[24]3427 (2)HBsAg(+); 14% HBeAg(+)2 (28.6)31 (29-38)31 (29-38)12.7 (11.1-16.6)NALiver injury was common but mild with no severe liver-related complications
2Chen et al[39]12315 (12.2)HBsAg(+) 6.7% HBeAg(+); 67% HBV DNA; > 20 IU/mL3 (20) entecavir25 (16-44)28 (19-58)13.2 (10.0-17.4)20 (14-28)The level of TBil was higher in patients with HBV infection (P < 0.05)
Wu et al[40]62070 (11.3)NANA50 (28-69) 40 (25-54) NANA33% of patients had abnormal ALT and AST; ALT/AST levels were higher in patients with HBV (P < 0.05)
He et al[25]57115 (2.63)NA3 (20) entecavir NANANANAHBV infection was observed to have a lower risk of severe events (P < 0.05)
Zhang et al[26]2323 (100)65.2% HBV carriers; 30.4% CHB; 4.3% cirrhosisNA38.6 (17.0-42.0)31.6 (15.0-36.8)24.9 (7.2-13.9)32.3 (13.5-41.0)26% of patients had abnormal liver function test results at admission