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©The Author(s) 2021.
World J Gastroenterol. Mar 7, 2021; 27(9): 782-793
Published online Mar 7, 2021. doi: 10.3748/wjg.v27.i9.782
Published online Mar 7, 2021. doi: 10.3748/wjg.v27.i9.782
Reference | Number of analyzed cases | HBV cases, n (%) | HBV status | Anti-HBV therapy, n (%) | ALT (U/L)1 | AST (U/L)1 | TBil (μmol/L)1 | GGT (U/L)1 | Note |
Zou et al[21] | 105 | 105 (100) | HBsAg(+), 94% HBeAg (–) | 13 (12.38); entecavir (9, 8.75); tenofovir (3, 2.86); lamivudine/defovir (1, 0.95) | 23 (15-33) | 28 (19-43) | 8.3 (6.6-12.8) | 24 (16-36) | Four patients developed ACLF and liver injury was associated with disease severity and worse prognosis |
Chen et al[22] | 326 | 20 (6.1) | HBsAg(+); HBeAg(–); HBV DNA < 100 IU/mL | NA | 28.00 (16.25-42.25) | 27.50 (22.00-42.25) | 10.55 (6.83-15.73) | 23.50 (15.50-35.25) | No differences in the level of liver function (HBV vs non-HBV) |
Liu et al[23] | 347 | 21 (6.4) | HBsAg(+); 95% HBeAg(–) | 1 (4.8) tenofovir | 30.40 (22.00-36.85) | 34.15 (27.00-39.58 | 12.60 (10.50-16.43) | 28.50 (17.25-43.42) | Three patients had HBV reactivation |
Li et al[24] | 342 | 7 (2) | HBsAg(+); 14% HBeAg(+) | 2 (28.6) | 31 (29-38) | 31 (29-38) | 12.7 (11.1-16.6) | NA | Liver injury was common but mild with no severe liver-related complications |
2Chen et al[39] | 123 | 15 (12.2) | HBsAg(+) 6.7% HBeAg(+); 67% HBV DNA; > 20 IU/mL | 3 (20) entecavir | 25 (16-44) | 28 (19-58) | 13.2 (10.0-17.4) | 20 (14-28) | The level of TBil was higher in patients with HBV infection (P < 0.05) |
Wu et al[40] | 620 | 70 (11.3) | NA | NA | 50 (28-69) | 40 (25-54) | NA | NA | 33% of patients had abnormal ALT and AST; ALT/AST levels were higher in patients with HBV (P < 0.05) |
He et al[25] | 571 | 15 (2.63) | NA | 3 (20) entecavir | NA | NA | NA | NA | HBV infection was observed to have a lower risk of severe events (P < 0.05) |
Zhang et al[26] | 23 | 23 (100) | 65.2% HBV carriers; 30.4% CHB; 4.3% cirrhosis | NA | 38.6 (17.0-42.0) | 31.6 (15.0-36.8) | 24.9 (7.2-13.9) | 32.3 (13.5-41.0) | 26% of patients had abnormal liver function test results at admission |
- Citation: Xiang TD, Zheng X. Interaction between hepatitis B virus and SARS-CoV-2 infections. World J Gastroenterol 2021; 27(9): 782-793
- URL: https://www.wjgnet.com/1007-9327/full/v27/i9/782.htm
- DOI: https://dx.doi.org/10.3748/wjg.v27.i9.782