Progress in elucidating the relationship between Helicobacter pylori infection and intestinal diseases

Table 1 Effects and factors of diseases in which Helicobacter pylori may affect the small and large intestines

Disease	Impact	Major factors suspected of being involved
Colon adenoma	Increase	Bacterial component, gastrin
Colon cancer	Increase	Bacterial component (especially VacA), gastrin, dysbiosis
Small intestinal ulcer	Increase	Mucosal permeability increased, dysbiosis
Irritable bowel syndrome	Involvement	Gastrointestinal hormones, SIBO
Ulcerative colitis	Decrease	Host immune response, antibacterial drug use
Crohn’s disease	Decrease	Host immune response
Fabry’s disease	Exacerbation	SIBO
FMF attack	Increase	SIBO
Celiac disease	Decrease	Immunological effects

SIBO: Small intestinal bacterial overgrowth; FMF: Familial Mediterranean fever; VacA: Vacuolating cytotoxin A.