MicroRNAs expression influence in ulcerative colitis and Crohn's disease: A pilot study for the identification of diagnostic biomarkers

Table 1 Demographic characteristics and clinical features of inflammatory bowel disease patients

	Ulcerative colitis	Crohn’s disease
Number of patients	10	10
Age at onset (yr, mean)	36.1 ± 18.31	31.6 ± 14.6
Sex, (%)
Male	40	30
Female	60	70
Race, (%)
Caucasian	100	90
Non-caucasian	0	10
Alcoholism, (%)	10	20
Smoking, (%)	20	10
Family history of IBD, (%)	10	0
Site of UC, (%)
Proctitis	20	-
Left-sided	30	-
Extensive	50	-
Site of CD, (%)
Ileal	-	20
Colonic	-	20
Ileocolonic	-	60

IBD: Inflammatory bowel disease; UC: Ulcerative colitis; CD: Crohn’s disease.

Table 2 Gene enrichment analysis of decreased microRNAs in ulcerative colitis patients compared with Crohn’s disease patients

Pathway	P value	FDR
Proteoglycans in cancer	2.27E-11	6.99E-09
FoxO signaling pathway	2.37E-11	3.64E-09
Pathways in cancer	7.49E-11	7.69E-09
Colorectal cancer	1.25E-07	5.51E-06
TGF-β signaling pathway	1.47E-07	4.53E-06
Signaling pathways regulating pluripotency of stem cells	4.72E-07	1.32E-05
Autophagy	5.58E-07	1.32E-05
ErbB signaling pathway	9.95E-07	2.19E-05
mTOR signaling pathway	3.70E-06	7.61E-05
MAPK signaling pathway	1.66E-05	2.22E-04

FoxO: Forkhead box protein O; TGF: Transforming growth factor-β; ErbB: Erythroblastic leukemia viral oncogene homolog; mTOR: Mammalian target of rapamycin; MAPK: Mitogen-activated protein kinase; FDR: False discovery rate-adjusted.