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©The Author(s) 2021.
World J Gastroenterol. Aug 28, 2021; 27(32): 5297-5305
Published online Aug 28, 2021. doi: 10.3748/wjg.v27.i32.5297
Published online Aug 28, 2021. doi: 10.3748/wjg.v27.i32.5297
Risk establishment | Prevention |
Questions to ask | |
(1) Ascites control: (a) Changes in the abdomen volume; (b) Fluid balance; (c) Weight; (d) Use of prescribed treatment; (2) Nutrition (any signs of malnutrition?); (3) Alcohol intake; (4) Surgeries in the abdomen; (5) Pre-existing hernias; (6) Employment (heavy lifting activities); (7) Comorbidities; (8) Constipation; (9) Medicaments used; and (10) Changes in the abdomen, umbilical area visual appearance | (1) Education; (2) Risk establishment; and (3) Risk management: (a) Lifestyle modification; (b) Management of the underlying liver disease; (c) Management of ascites; (d) Doctor-patient communication; and (e) Communication between medical specialists |
Patients with UH | |
(1) All the above; (2) Avoid heavy lifting, rapid movement; (3)Abdominal surgeon consult; and (4) Elective surgery in stable patients |
Treatment | |
Main measures | Moderate restriction of sodium intake, 80–120 mmoL/d (4.6-6.9 g of salt/d) |
Adequate nutrition: Protein-rich diet (2000 kcal/d, protein–40-50 g/d), vitamin therapy | |
Correction of electrolyte imbalance | |
Adequate fluid intake: No restriction needed in patients with normal serum sodium concentration; in hyponatremic patients (< 130 mmoL/L), restrict fluid intake to 1.0-1.5 L/d | |
Daily track of weight (or measure fluid intake and diuresis) | |
The maximum recommended weight loss during diuretic therapy: (1) 0.5 kg/d in patients without edema; and (2) 1 kg/d in patients with edema | |
Mild and moderate ascites (grade Iº-IIº) | Aldosterone antagonists: Spironolactone 50-100 mg/d (maximum of 400 mg/d) ± loop diuretics: Furosemide 20-40 mg/d (maximum of 160 mg/d) |
Torasemide (10-40 mg/d) if no response to furosemide | |
Distal diuretics: Amiloride 5-20 mg/d; triamterene 100 mg 2 k./d. (if aldosterone antagonists are not tolerated) | |
Combined dosage of diuretics: Spironolactone 50-100-200-300-400 mg/d (in 100 mg steps) + furosemide 20-40-80-120-160 mg/d (in 40 mg steps) (or adequate doses of other diuretics) | |
Large ascites (grade IIIº) | LVP |
Albumin infusion (8 g/L of ascitic fluid removed) | |
Minimal effective dose of diuretics to prevent the re-accumulation of ascites after LVP | |
Refractory ascites | Repeated partial or large volume paracentesis + albumin infusion |
Withdrawn diuretics | |
Transjugular intrahepatic portosystemic shunt | |
Alternative drugs: (1) α1 adrenergic agonists–midodrine 7.5 mg 3 times/d; (2) Vasopressin analog–terlipressin 1-2 mg/d intravenous; and (3) α2 adrenergic agonists–clonidine | |
Alfapump system | |
Liver transplantation |
- Citation: Strainiene S, Peciulyte M, Strainys T, Stundiene I, Savlan I, Liakina V, Valantinas J. Management of Flood syndrome: What can we do better? World J Gastroenterol 2021; 27(32): 5297-5305
- URL: https://www.wjgnet.com/1007-9327/full/v27/i32/5297.htm
- DOI: https://dx.doi.org/10.3748/wjg.v27.i32.5297