New hope for hepatitis C virus: Summary of global epidemiologic changes and novel innovations over 20 years

doi:10.3748/wjg.v27.i29.4818

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Aug 7, 2021 (publication date) through Nov 28, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 7, 2021; 27(29): 4818-4830
Published online Aug 7, 2021. doi: 10.3748/wjg.v27.i29.4818

Table 1 Classification of direct-acting antiviral agents[29]

Class	Drug name	HCV genotype
NS3/4A inhibitor	Boceprevir¹	Genotypes 1a and 1b
	Telaprevir¹
	Simeprevir
	Asunaprevir
	Paritaprevir
	Grazoprevir
	Glecaprevir
	Voxilaprevir
NS5A inhibitor	Daclatasvir	All HCV genotypes
	Ledipasvir
	Ombitasvir
	Elbasvir
	Velpatasvir
	Pibrentasvir
NS5B polymerase inhibitor: Nucleoside analogs	Sofosbuvir	All HCV genotypes
NS5B polymerase inhibitor: Non-nucleoside analogs	Dasabuvir	Genotypes 1a and 1b

¹First generation direct-acting antiviral agents.

HCV: Hepatitis C virus.

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Citation: Dennis BB, Naji L, Jajarmi Y, Ahmed A, Kim D. New hope for hepatitis C virus: Summary of global epidemiologic changes and novel innovations over 20 years. World J Gastroenterol 2021; 27(29): 4818-4830
URL: https://www.wjgnet.com/1007-9327/full/v27/i29/4818.htm
DOI: https://dx.doi.org/10.3748/wjg.v27.i29.4818