Cascade of care for children and adolescents with chronic hepatitis C

Table 1 Completed studies of direct acting antivirals regimens in children and adolescents

Ref.	Year	Participant age in years (n)	HCV genotype	Therapy (duration)	SVR12 (%)
Balistreri et al[50]	2016	12-17 (100)	1	Ledipasvir 90 mg + sofosbuvir 400 mg (12 wk)	98
Wirth et al[51]	2017	12-17 (52)	2 or 3	Sofosbuvir 400 mg + ribavirin (variable)	98
Hashmi et al[52]	2017	5-18 (35)	1 or 3	Sofosbuvir 400 mg + ribavirin (variable)	97
El-Khayat et al[53]	2018	12-17 (144)	1, 4-6	Ledipasvir 45 mg + sofosbuvir 200 mg (12 wk)	99
Murray et al[54]	2018	6-11 (90)	1	Ledipasvir 45 mg + sofosbuvir 200 mg (12 wk)	98
El-Karaksy et al[55]	2018	12-18 (40)	4	Ledipasvir 90 mg + sofosbuvir 400 mg (12 wk)	100
Leung et al[56]	2018	12-17 (38)	1 or 4	Ombitasvir/paritaprevir/ritonavir + dasabuvir +/- ribavirin (variable)	100
Alkaaby et al[57]	2018	7-18 (22)		Ledipasvir + sofosbuvir +/- ribavirin (variable)	91
Tucci et al[58]	2018	0.5 (1)	4	Ledipasvir 22.5 mg + sofosbuvir 100 mg (12 wk)	100
El-Shabrawi et al[59]	2018	6-12 (20)	4	Ledipasvir 45 mg + sofosbuvir 200 mg (12 wk)	95
El-Shabrawi et al[60]	2018	12-17 (10)	1-6	Sofosbuvir 400 mg + daclatasvir 60 mg (8 wk)	100
Yakoot et al[61]	2018	12-17 (30)	4	Sofosbuvir + daclatasvir (12 wk)	97
Quintero et al[62]	2019	6-18 (9)	1 or 4	Ledipasvir + sofosbuvir (variable)	100
Ghaffar et al[63]	2019	8-18 (40)	4	Sofosbuvir + daclatasvir (variable)	97.5
Fouad et al[64]	2019	11-17.5 (51)	4	Ledipasvir 90 mg + sofosbuvir 400 mg (12 wk)	100
Ohya et al[65]	2019	10-13 (3)	1b	Ombitasvir + paritaprevir + ritonavir (12 wk)Or glecaprevir + pibrenastavir (8 wk)	100
El-Shabrawi et al[66]	2019	8-17 (20)	4	Sofosbuvir + Daclatasvir (12 wk)	100
Serranti et al[67]	2019	12-17 (14)	1	Ledipasvir 90 mg + sofosbuvir 400 mg (8 wk)	100
Marascio et al[68]	2019	13, 16 (2)	4	Ledipasvir 90 mg + sofosbuvir 400 mg (12 wk)	100
Fouad et al[69]	2020	12-18 (46)	Not performed	Ledipasvir 180 mg + sofosbuvir 400 mg (12 wk)	98
Kamal et al[70]	2020	3-6 (22)	4	Ledipasvir 45 mg + sofosbuvir 200 mg (8 or 12 wk)	100
El-Araby et al[71]	2020	9-12 (100)	4	Ledipasvir 90 mg + sofosbuvir 400 mg (12 wk)	100
Rosenthal et al[72]	2020	3-11 (54)	1 or 4	Sofosbuvir 400 mg + ribavirin (variable)	98
Schwarz et al[73]	2020	3-< 6 (34)	1 or 4	Ledipasvir + sofosbuvir (variable)	97
Jonas et al74]	2020	12-17 (47)	1-4	Glecaprevir 300 mg + pibrentasvir 120 mg (8-16 wk)	100
Wirth et al[75]	2020	3-17 (57)	1 or 4	Elbasvir + grazoprevir (12 wk)	100
Sokal et al[76]	2020	3-17 (216)	1-4, 6	Sofosbuvir + velpatasvir (12 wk)	92
Behairy et al[77]	2020	4-10 (30)	4	Ledipasvir 45 mg + sofosbuvir 200 mg (8 wk)	100

Table adapted from Squires et al[17]. HCV: Hepatitis C virus.