Copyright
©The Author(s) 2020.
World J Gastroenterol. Feb 28, 2020; 26(8): 828-838
Published online Feb 28, 2020. doi: 10.3748/wjg.v26.i8.828
Published online Feb 28, 2020. doi: 10.3748/wjg.v26.i8.828
Features | n = 582 |
Age [yr, median (range)] | 61 (29-82) |
Gender (male/female) | 319(54.8)/263(45.2) |
Tumour location (head/body, tail) | 243(41.8)/339 (58.2) |
Preoperative CA19-9 (> 37 U/mL/≤ 37 U/mL) | 440 (75.6)/142 (24.4) |
HALP (> 44.56/≤ 44.56) | 351 (60.3)/231 (39.7) |
NLR (> 2.20/≤ 2.20) | 287 (49.3)/295 (50.7) |
PLR (> 112.94/≤ 112.94) | 331 (56.9)/251 (43.1) |
PNI (> 53.10/≤ 53.10) | 249 (42.8)/333 (57.2) |
Tumour size (cm, median (range)) | 4.0 (0.3-11.5) |
Lymph node metastasis (more than 3/1-3/0 positive lymph nodes) | 75 (12.9)/210 (36.1)/297 (51.0) |
Total lymph nodes resected [median (range)] | 12 (1-69) |
TNM stage (IA/IB/IIA/IIB/III) | 39 (6.7)/164 (28.2)/94 (16.2)/210 (36.0)/75 (12.9) |
Differentiation (well, moderate/poor) | 361 (62.0)/221 (38.0) |
Neural invasion (yes/no) | 476 (81.8)/106 (18.2) |
Microvascular invasion (yes/no) | 126 (21.6)/456 (78.4) |
Features | HALP | ||
Low (≤ 44.56, n = 231) | High (> 44.56, n = 351) | P value | |
Age (yr) | 0.161 | ||
≤ 62 | 112 | 191 | |
> 62 | 119 | 160 | |
Gender | 0.005 | ||
Female | 121 | 142 | |
Male | 110 | 209 | |
Preoperative CA19-9 | 0.473 | ||
≤ 37 U/mL | 60 | 82 | |
> 37 U/mL | 171 | 269 | |
NLR | < 0.001 | ||
≤ 2.20 | 77 | 218 | |
> 2.20 | 154 | 133 | |
PLR | < 0.001 | ||
≤ 112.94 | 17 | 234 | |
> 112.94 | 214 | 117 | |
PNI | < 0.001 | ||
≤ 53.10 | 187 | 146 | |
> 53.10 | 44 | 205 | |
Tumor location | < 0.001 | ||
Head | 122 | 121 | |
Body/Tail | 109 | 230 | |
TNM stage | 0.008 | ||
IA | 13 | 26 | |
IB | 59 | 105 | |
IIA | 30 | 64 | |
IIB | 86 | 124 | |
III | 43 | 32 | |
Tumor size | 0.718 | ||
≤ 4.0 cm | 146 | 227 | |
> 4.0 cm | 85 | 124 | |
Lymph node metastasis | 0.002 | ||
0 | 102 | 195 | |
1-3 | 86 | 124 | |
> 3 | 43 | 32 | |
Tumor differentiation | 0.032 | ||
Well/Moderate | 131 | 230 | |
Poor | 100 | 121 | |
Neural invasion | 0.672 | ||
No | 44 | 62 | |
Yes | 187 | 289 | |
Microvascular invasion | 1.000 | ||
No | 173 | 283 | |
Yes | 58 | 68 |
Features | OS | RFS | ||||||||||
Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||||||
HR | 95%CI | P value | HR | 95%CI | P value | HR | 95%CI | P value | HR | 95%CI | P value | |
Age | 0.874 | 0.683-1.119 | 0.286 | NS | 0.896 | 0.737-1.090 | 0.273 | NS | ||||
Gender (male versus female) | 1.312 | 1.021-1.686 | 0.034 | NS | 1.196 | 0.982-1.456 | 0.075 | NS | ||||
Tumor location (body/tail versus head) | 0.925 | 0.722-1.185 | 0.538 | NS | 0.976 | 0.806-1.188 | 0.805 | NS | ||||
Preoperative CA19-9 (> 37 U/mL/≤ 37 U/mL) | 1.871 | 1.355-2.585 | < 0.001 | 1.629 | 1.176-2.258 | 0.003 | 1.543 | 1.218-1.955 | < 0.001 | 1.45 | 1.143-1.839 | 0.002 |
HALP (> 44.56/≤ 44.56) | 0.605 | 0.472-0.774 | < 0.001 | 0.601 | 0.433-0.835 | < 0.001 | 0.633 | 0.520-0.772 | < 0.001 | 0.678 | 0.556-0.828 | < 0.001 |
NLR (> 2.20/≤ 2.20) | 1.654 | 1.289-2.122 | < 0.001 | 1.394 | 1.062-1.831 | 0.017 | 1.442 | 1.185-1.754 | < 0.001 | NS | ||
PLR (> 112.94/≤ 112.94) | 1.272 | 0.990-1.634 | 0.06 | NS | 1.277 | 1.047-1.557 | 0.016 | NS | ||||
PNI (> 53.10/≤ 53.10) | 0.663 | 0.511-0.860 | 0.002 | NS | 0.764 | 1.650-1.970 | 0.024 | NS | ||||
TNM stage (III/IIB/IIA/IB/IA) | 1.39 | 1.240-1.558 | < 0.001 | 1.302 | 1.161-1.461 | < 0.001 | 1.294 | 1.184-1.413 | < 0.001 | 1.236 | 1.132-1.350 | < 0.001 |
Tumor size (> 4.0/≤ 4.0 cm) | 1.586 | 1.237-2.034 | < 0.001 | NA | 1.334 | 1.092-1.630 | 0.005 | NA | ||||
Lymph node metastasis (more than 3/1-3/0 nodes) | 1.658 | 1.395-1.970 | < 0.001 | NA | 1.533 | 1.334-1.761 | < 0.001 | NA | ||||
Total lymph nodes resected | 0.992 | 0.979-1.006 | 0.246 | NS | 1.001 | 0.991-1.011 | 0.868 | NS | ||||
Differentiation (well, moderate versus poor) | 2.192 | 1.711-2.808 | < 0.001 | 1.988 | 1.547-2.555 | < 0.001 | 1.791 | 1.467-2.187 | < 0.001 | 1.672 | 1.367-2.043 | < 0.001 |
Neural invasion (yes versus no) | 1.533 | 1.078-2.182 | 0.018 | NS | 1.358 | 1.041-1.772 | 0.024 | NS | ||||
Microvascular invasion (yes versus no) | 1.424 | 1.070-1.894 | 0.015 | NS | 1.306 | 1.037-1.646 | 0.024 | NS |
- Citation: Xu SS, Li S, Xu HX, Li H, Wu CT, Wang WQ, Gao HL, Jiang W, Zhang WH, Li TJ, Ni QX, Liu L, Yu XJ. Haemoglobin, albumin, lymphocyte and platelet predicts postoperative survival in pancreatic cancer. World J Gastroenterol 2020; 26(8): 828-838
- URL: https://www.wjgnet.com/1007-9327/full/v26/i8/828.htm
- DOI: https://dx.doi.org/10.3748/wjg.v26.i8.828