Retrospective Study
Copyright ©The Author(s) 2020.
World J Gastroenterol. Feb 28, 2020; 26(8): 828-838
Published online Feb 28, 2020. doi: 10.3748/wjg.v26.i8.828
Table 1 Clinicopathological features of patients with resected pancreatic cancer, n (%)
Featuresn = 582
Age [yr, median (range)]61 (29-82)
Gender (male/female)319(54.8)/263(45.2)
Tumour location (head/body, tail)243(41.8)/339 (58.2)
Preoperative CA19-9 (> 37 U/mL/≤ 37 U/mL)440 (75.6)/142 (24.4)
HALP (> 44.56/≤ 44.56)351 (60.3)/231 (39.7)
NLR (> 2.20/≤ 2.20)287 (49.3)/295 (50.7)
PLR (> 112.94/≤ 112.94)331 (56.9)/251 (43.1)
PNI (> 53.10/≤ 53.10)249 (42.8)/333 (57.2)
Tumour size (cm, median (range))4.0 (0.3-11.5)
Lymph node metastasis (more than 3/1-3/0 positive lymph nodes)75 (12.9)/210 (36.1)/297 (51.0)
Total lymph nodes resected [median (range)]12 (1-69)
TNM stage (IA/IB/IIA/IIB/III)39 (6.7)/164 (28.2)/94 (16.2)/210 (36.0)/75 (12.9)
Differentiation (well, moderate/poor)361 (62.0)/221 (38.0)
Neural invasion (yes/no)476 (81.8)/106 (18.2)
Microvascular invasion (yes/no)126 (21.6)/456 (78.4)
Table 2 Relationship between hemoglobin, albumin, lymphocyte, and platelet and clinical features in patients with resected pancreatic cancer
FeaturesHALP
Low (≤ 44.56, n = 231)High (> 44.56, n = 351)P value
Age (yr)0.161
≤ 62112191
> 62119160
Gender0.005
Female121142
Male110209
Preoperative CA19-90.473
≤ 37 U/mL6082
> 37 U/mL171269
NLR< 0.001
≤ 2.2077218
> 2.20154133
PLR< 0.001
≤ 112.9417234
> 112.94214117
PNI< 0.001
≤ 53.10187146
> 53.1044205
Tumor location< 0.001
Head122121
Body/Tail109230
TNM stage0.008
IA1326
IB59105
IIA3064
IIB86124
III4332
Tumor size0.718
≤ 4.0 cm146227
> 4.0 cm85124
Lymph node metastasis0.002
0102195
1-386124
> 34332
Tumor differentiation0.032
Well/Moderate131230
Poor100121
Neural invasion0.672
No4462
Yes187289
Microvascular invasion1.000
No173283
Yes5868
Table 3 Univariate and multivariate analysis for overall survival in subgroups of patients with resected pancreatic cancer
FeaturesOS
RFS
Univariate analysis
Multivariate analysis
Univariate analysis
Multivariate analysis
HR95%CIP valueHR95%CIP valueHR95%CIP valueHR95%CIP value
Age0.8740.683-1.1190.286NS0.8960.737-1.0900.273NS
Gender (male versus female)1.3121.021-1.6860.034NS1.1960.982-1.4560.075NS
Tumor location (body/tail versus head)0.9250.722-1.1850.538NS0.9760.806-1.1880.805NS
Preoperative CA19-9 (> 37 U/mL/≤ 37 U/mL)1.8711.355-2.585< 0.0011.6291.176-2.2580.0031.5431.218-1.955< 0.0011.451.143-1.8390.002
HALP (> 44.56/≤ 44.56)0.6050.472-0.774< 0.0010.6010.433-0.835< 0.0010.6330.520-0.772< 0.0010.6780.556-0.828< 0.001
NLR (> 2.20/≤ 2.20)1.6541.289-2.122< 0.0011.3941.062-1.8310.0171.4421.185-1.754< 0.001NS
PLR (> 112.94/≤ 112.94)1.2720.990-1.6340.06NS1.2771.047-1.5570.016NS
PNI (> 53.10/≤ 53.10)0.6630.511-0.8600.002NS0.7641.650-1.9700.024NS
TNM stage (III/IIB/IIA/IB/IA)1.391.240-1.558< 0.0011.3021.161-1.461< 0.0011.2941.184-1.413< 0.0011.2361.132-1.350< 0.001
Tumor size (> 4.0/≤ 4.0 cm)1.5861.237-2.034< 0.001NA1.3341.092-1.6300.005NA
Lymph node metastasis (more than 3/1-3/0 nodes)1.6581.395-1.970< 0.001NA1.5331.334-1.761< 0.001NA
Total lymph nodes resected0.9920.979-1.0060.246NS1.0010.991-1.0110.868NS
Differentiation (well, moderate versus poor)2.1921.711-2.808< 0.0011.9881.547-2.555< 0.0011.7911.467-2.187< 0.0011.6721.367-2.043< 0.001
Neural invasion (yes versus no)1.5331.078-2.1820.018NS1.3581.041-1.7720.024NS
Microvascular invasion (yes versus no)1.4241.070-1.8940.015NS1.3061.037-1.6460.024NS