Liver stiffness and perfusion changes for hepatic sinusoidal obstruction syndrome in rabbit model

doi:10.3748/wjg.v26.i7.706

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 26, Issue 7

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (8941)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-2) series, Tables (1-5) series.

Item

Count

PDF

403

WORD

130

HTML

3582

Figures (1-2)

389

Tables (1-5)

362

Sum=4866

Featured Article

The chart showing Browse series, Download series.

Item

Count

Browse

587

Download

957

Sum=1544

Publishing Process of This Article

Item

Count

Browse

1032

Download

1499

Sum=2531

Feb 21, 2020 (publication date) through Feb 21, 2025

Times Cited of This Article

Times Cited (9)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Gastroenterol. Feb 21, 2020; 26(7): 706-716
Published online Feb 21, 2020. doi: 10.3748/wjg.v26.i7.706

Table 1 Comparison of laboratory results between control and sinusoidal obstruction syndrome groups

Results	Days	Control group	SOS group	Differences	P value
AST (IU/L)	0	32.67 (-55.57, 120.9)	20.5 (-41.89, 82.89)	12.17 (-95.9, 120.23)	0.818
	3	24.67 (-63.57, 112.9)	23 (-39.39, 85.39)	1.67 (-106.4, 109.73)	0.975
	10	20.67 (-67.57, 108.9)	26.4 (-42.5, 95.3)	-5.73 (-117.68, 106.22)	0.917
	20	26.33 (-61.9, 114.57)	221.34 (130.35, 312.33)	-195.01 (-321.75, -68.26)	0.004^b
ALT (IU/L)	0	38 (3.97, 72.03)	33.17 (9.11, 57.23)	4.83 (-36.84, 46.51)	0.813
	3	44.67 (10.64, 78.69)	41.83 (17.77, 65.89)	2.83 (-38.84, 44.51)	0.890
	10	33.67 (-0.36, 67.69)	25.41 (-1.18, 51.99)	8.26 (-34.92, 51.44)	0.697
	20	40.67 (6.64, 74.69)	109.35 (74.12, 144.58)	-68.69 (-117.67, -19.71)	0.008^b
Tbil (mg/dL)	0	0.27 (-0.18, 0.72)	0.42 (0.1, 0.73)	-0.15 (-0.7, 0.4)	0.579
	3	0.63 (0.18, 1.08)	0.52 (0.2, 0.83)	0.12 (-0.43, 0.67)	0.666
	10	0.9 (0.45, 1.35)	1.18 (0.82, 1.53)	-0.28 (-0.85, 0.29)	0.328
	20	0.53 (0.08, 0.98)	0.96 (0.49, 1.43)	-0.43 (-1.07, 0.22)	0.186
Dbil (mg/dL)	0	0.1 (-0.08, 0.28)	0.12 (-0.01, 0.25)	-0.02 (-0.24, 0.21)	0.879
	3	0.13 (-0.05, 0.32)	0.17 (0.04, 0.3)	-0.03 (-0.26, 0.19)	0.760
	10	0.17 (-0.02, 0.35)	0.26 (0.12, 0.4)	-0.09 (-0.32, 0.14)	0.411
	20	0.13 (-0.05, 0.32)	0.47 (0.28, 0.65)	-0.33 (-0.59, -0.08)	0.013^a

Values are estimated mean and 95% confidence interval.

^aP < 0.05.

^bP < 0.01. SOS: Sinusoidal obstruction syndrome; AST: Serum aspartate aminotransferase; ALT: Alanine aminotransferase; Tbil: Total bilirubin; Dbil: Direct bilirubin.

Table 2 Comparison of quantitative imaging results between control and sinusoidal obstruction syndrome groups

Parameters	Days	Control group	SOS group	Differences	P value
Liver stiffness (kPa)	0	4.35 (2.82, 5.88)	3.89 (2.81, 4.97)	0.46 (-1.41, 2.33)	0.623
	3	5.68 (4.16, 7.21)	6.38 (5.3, 7.45)	-0.69 (-2.56, 1.18)	0.458
	10	4.02 (2.49, 5.54)	9.48 (8.29, 10.66)	-5.46 (-7.39, -3.53)	< 0.001^b
	20	4.67 (3.14, 6.19)	7.71 (6.17, 9.25)	-3.04 (-5.21, -0.87)	0.007^b
VMI 55 keV (HU)	0	153.18 (137.07, 169.29)	158.77 (147.38, 170.16)	-5.59 (-25.33, 14.14)	0.550
	3	147.18 (131.07, 163.29)	167.68 (155.92, 179.44)	-20.5 (-40.44, -0.55)	0.045^a
	10	129.05 (112.94, 145.16)	185.42 (173.62, 197.22)	-56.37 (-76.34, -36.4)	< 0.001^b
	20	148.95 (132.83, 165.06)	179.81 (166.5, 193.11)	-30.86 (-51.69, -10.03)	0.006^b
Iodine concentration (mg/mL)	0	24.8 (20.76, 28.84)	24.2 (21.34, 27.05)	0.61 (-4.34, 5.55)	0.794
	3	20.72 (16.69, 24.76)	26.73 (23.79, 29.67)	-6.01 (-11, -1.02)	0.022^a
	10	19.16 (15.12, 23.19)	31.86 (28.91, 34.8)	-12.7 (-17.7, -7.7)	< 0.001^b
	20	23.85 (19.81, 27.88)	35.14 (31.84, 38.44)	-11.29 (-16.49, -6.1)	< 0.001^b

Values are estimated mean and 95% confidence interval.

^aP < 0.05.

^bP < 0.01. SOS: Sinusoidal obstruction syndrome; VMI: Virtual monochromatic image; HU: Hounsfield unit.

Table 3 Comparison of laboratory results between days 0 and 20

Results	Groups	Day 0	Day 20	Difference	P value
AST (IU/L)	Control	32.67 (-55.57, 120.9)	26.33 (-61.9, 114.57)	6.33 (-118.48, 131.15)	0.916
AST (IU/L)	SOS	20.5 (-41.89, 82.89)	221.34 (130.35, 312.33)	-200.84 (-310.9, -90.78)	0.001^b
ALT (IU/L)	Control	38 (3.97, 72.03)	40.67 (6.64, 74.69)	-2.67 (-51.54, 46.21)	0.910
ALT (IU/L)	SOS	33.17 (9.11, 57.23)	109.35 (74.12, 144.58)	-76.19 (-119.14, -33.24)	0.001^b
Tbil (mg/dL)	Control	0.27 (-0.18, 0.72)	0.53 (0.08, 0.98)	-0.27 (-0.9, 0.37)	0.387
Tbil (mg/dL)	SOS	0.42 (0.1, 0.73)	0.96 (0.49, 1.43)	-0.54 (-1.1, 0.02)	0.057
Dbil (mg/dL)	Control	0.1 (-0.08, 0.28)	0.13 (-0.05, 0.32)	-0.03 (-0.29, 0.22)	0.792
Dbil (mg/dL)	SOS	0.12 (-0.01, 0.25)	0.47 (0.28, 0.65)	-0.35 (-0.57, -0.13)	0.004^b

Values are presented as estimated mean and 95% confidence interval.

^bP < 0.01. SOS: sinusoidal obstruction syndrome; AST: Serum aspartate aminotransferase; ALT: Alanine aminotransferase; Tbil: Total bilirubin; Dbil: Direct bilirubin.

Table 4 Comparison of quantitative imaging results between day 0 and 20

Parameters	Groups	Day 0	Day 20	Difference	P value
Liver stiffness (kPa)	Control	4.35 (2.82, 5.88)	4.67 (3.14, 6.19)	-0.32 (-2.32, 1.69)	0.752
Liver stiffness (kPa)	SOS	3.89 (2.81, 4.97)	7.71 (6.17, 9.25)	-3.82 (-5.61, -2.02)	< 0.001^b
VMI 55 keV (HU)	Control	153.18 (137.07, 169.29)	148.95 (132.83, 165.06)	4.23 (-8.48, 16.95)	0.510
VMI 55 keV (HU)	SOS	158.77 (147.38, 170.16)	179.81 (166.5, 193.11)	-21.04 (-32.7, -9.37)	0.001^b
Iodine concentration (mg/mL)	Control	24.8 (20.76, 28.84)	23.85 (19.81, 27.88)	0.95 (-2.12, 4.03)	0.539
Iodine concentration (mg/mL)	SOS	24.2 (21.34, 27.05)	35.14 (31.84, 38.44)	-10.94 (-13.77, -8.12)	< 0.001^b

Values are presented as estimated mean and 95% confidence interval.

^bP < 0.01. SOS: Sinusoidal obstruction syndrome; VMI: Virtual monochromatic image; HU: Hounsfield unit.

Table 5 Assessment of correlation between final pathologic scores and laboratory results and quantitative imaging parameters

Results	r (95%CI)	P value
AST (IU/L)	0.323 (-0.511, 0.83)	0.453
ALT (IU/L)	0.491 (-0.358, 0.881)	0.230
Tbil (mg/dL)	0.156 (-0.623, 0.771)	0.726
Dbil (mg/dL)	0.261 (-0.557, 0.809)	0.551
Liver stiffness (kPa)	0.635 (-0.171, 0.919)	0.094
VMI 55 keV (HU)	0.587 (-0.241, 0.906)	0.133
Iodine concentration (mg/mL)	0.611 (-0.207, 0.913)	0.112

AST: Serum aspartate aminotransferase; ALT: Alanine aminotransferase; Tbil: Total bilirubin; Dbil: Direct bilirubin; VMI: Virtual monochromatic image; HU: Hounsfield unit; CI: Confidence interval.

Citation: Shin J, Yoon H, Cha YJ, Han K, Lee MJ, Kim MJ, Shin HJ. Liver stiffness and perfusion changes for hepatic sinusoidal obstruction syndrome in rabbit model. World J Gastroenterol 2020; 26(7): 706-716
URL: https://www.wjgnet.com/1007-9327/full/v26/i7/706.htm
DOI: https://dx.doi.org/10.3748/wjg.v26.i7.706