High prevalence of hepatic steatosis and vascular thrombosis in COVID-19: A systematic review and meta-analysis of autopsy data

Table 1 Main characteristics of studies included in the analysis

Ref.	Date	Country	Sources of samples	Nº of pts	Age (yr)	Gender	Ethnicity	Comorbidities
Barton et al[17]	April 2020	United States	Autopsy	2	77 and 42	2 Males	Not reported	Obesity (2/2), hypertension (1/2), splenectomy (1/2), myotonic dystrophy (1/2)
Bradley et al[18]	April 2020	United States	Autopsy	12	70.4 (42-84)	5 Males and 7 females	Not reported	Not reported
Bryce et al[29]	May 2020	United States	Autopsy	22	Not reported	Not reported	Not reported	Not reported
Buja et al[19]	May 2020	United States	Autopsy	3	62, 34 and 48	2 Males and 1 female	2 Hispanic and 1 afro-american	Obesity (3/3), hypertension (1/3), heart failure (1/3), diabetes (1/3) and microcytic anemia (1/3)
Craver et al[20]	April 2020	United States	Autopsy	1	17	Male	Afro-american	None
Lacy et al[21]	April 2020	United States	Autopsy	1	58	Female	Not reported	Diabetes, obesity, hyperlipidemia, Asthma, and chronic lower extremity swelling with ulceration
Lax et al[27]	May 2020	Austria	Autopsy	11	80.5 (66-91)	8 Males and 3 females	Not reported	Hypertension (9/11), diabetes mellitus (5/11), coronary artery disease (2/11), previous malignant disease (2/11), COPD (2/11), cerebrovascular disease (4/11), and dementia (4/11)
Martines et al[22]	May 2020	United States	Autopsy	8	73.5	4 Males and 4 females	7 Caucasian and 1 hispanic	Arterial hypertension (6/8), chronic kidney disease (6/8) cardiovascular disease (6/8), obesity (5/8), diabetes (4/8), chronic lung disease (2/8), immunocompromised condition (3/8), among others
Menter et al[23]	May 2020	Switzerland	Autopsy	17	Adult patients	Not specified	Not specified	Not specified
Prilutskiy et al[28]	March 2020	United States	Autopsy	4	64-91	3 Males and 1 female	3 Afro-american and 1 caucasian	Not reported
Remmelink et al[24]	May 2020	Belgium	Autopsy	17	72 [62-77]	12 Males and 5 females	Not reported	Cirrhosis (2/17), liver transplantation (1/17), hypertension (10/17), diabetes (9/17), cerebrovascular disease (4/17), coronary artery disease (4/17), and solid cancer (4/17)
Schaller et al[25]	May 2020	Germany	Autopsy	10	79 (64-90)	7 Males and 3 females	Not reported	Fatty liver disease (1/10), hypertension (7/10), atrial fibrillation (4/10), chronic kidney failure (3/10), COPD (2/10), heart failure (2/10), obesity (2/10), diabetes (1/10), among others
Sonzogni et al[16]	May 2020	Italy	Autopsy	48	71.2 (32-87)	35 Males and 13 females	Not reported	Not specified
Tian et al[14]	April 2020	China	Autopsy	4	78, 74, 81, 59	3 Males and 1 female	Asian	Chronic lymphocytic leukemia; Cirrhosis, DM2, HTA
Varga et al[13]	April 2020	Switzerland	Autopsy	1	58	Female	Not reported	Diabetes, hypertension, and obesity
Wang et al[26]	May 2020	China	Autopsy	2	50 and 79	1 Male and 1 female	2 Asian	Not reported
Xu et al[12]	February 2020	China	Autopsy	1	50	Male	Asian	Not reported
Yao et al[30]	May 2020	China	Autopsy	3	63, 69, and 79	2 Males and 1 female	3 Asian	Diabetes (1/3), hyperglycemia (1/3) bronchiectasis (1/3), solid cancer (1/3)