Colonic vitamin D receptor expression is inversely associated with disease activity and jumonji domain-containing 3 in active ulcerative colitis

Table 1 Demographic characteristics of ulcerative colitis patients and controls

Variable	UC patients, n = 100	HC, n = 56	P value
Age [mean (SD), yr]	45.5 (14.2)	45.8 (10.0)	0.8731
Sex (female: male)	57:43	32:24	0.9862
Smoker, n (%)	45 (45.0)	21 (37.5)	0.3632
BMI [mean (SD), kg/m2]	21.2 (3.4)	20.4 (2.1)	0.1011
25 (OH) D [mean (SD), nmol/L]	13.7 (2.8)	16.2 (2.5)	< 0.0011
Disease Location, n (%)
Ulcerative proctitis (E1)	8 (8.0)	-	-
Left-sided colitis (E2)	54 (54.0)	-	-
Extensive colitis (E3)	38 (38.0)	-	-
Severity of UC, n (%)
Mild	29 (29.0)	-	-
Moderate	32 (32.0)	-	-
Severe	39 (39.0)	-	-
Current medications, n (%)
SASP/5-ASA	80 (80.0)	-	-
Immunosuppressants	2 (2.0)	-	-
Steroids	31 (31.0)	-	-
Biologics	4 (4.0)	-	-
Others	22 (22.0)	-	-
Duration of disease mean (SD), yr	5.4 (6.0)	-	-

¹Independent sample t tests.

²χ² test. 5-ASA: 5-Aminosalicylic acid; SASP: Sulfasalazine; SD: Standard deviation; UC: Ulcerative colitis.

Table 2 Laboratory indexes characteristics of ulcerative colitis patients with different disease activity

Indexes	Mild activity, n = 29	Moderate activity, n = 32	Severe activity, n = 39
Serum vitamin D (ng/mL)	14.8 ± 2.4	14.2 ± 2.4	11.7 ± 3.1
WBC (109/L)	6.90 (4.53-12.81)	7.13 (0.32-6.02)	7.13 (3.28-17.59)
CRP (mg/L)	1.51 (0.38-66.23)	9.90 (0.30-168.78)	70.67 (1.44-190.07)
ESR (mm/h)	8 (3-34)	23 (3-95)	41 (7-127)
ALP (U/L)	81 (49-140)	85 (40-602)	77.50 (53-109)
PLT (109/L)	222 (113-363)	260 (130-518)	286 (125-500)
HGB (g/L)	137 (74-155)	115 (59-164)	115 (55-149)
ALB (g/L)	42.11 ± 4.97	37.25 ± 6.13	31.31 ± 4.79
Ca (mmol/L)	2.31 (1.01-2.63)	2.23 (1.67-2.49)	2.06 (1.82-2.31)
P (mmol/L)	1.12 ± 0.20	1.17 ± 0.21	1.11 ± 0.27
Mayo score	5 (3-5)	8 (6-10)	11.5 (11.0-12.0)

Values are given as the mean ± SD if they follow a normal distribution, otherwise given as medians (minimum and maximum). ALB: Albumin; ALP: Alkaline phosphatase; Ca: Calcium; CRP: C-reactive protein; ESR: Erythrocyte sedimentation rate; HGB: Hemoglobin; P: Phosphorus; PLT: Platelet; UC: Ulcerative colitis.