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©The Author(s) 2020.
World J Gastroenterol. Oct 14, 2020; 26(38): 5849-5862
Published online Oct 14, 2020. doi: 10.3748/wjg.v26.i38.5849
Published online Oct 14, 2020. doi: 10.3748/wjg.v26.i38.5849
Table 1 Demographic characteristic of cases with cirrhosis and controls, n (%)
| Cirrhosis (n = 5258) | Control (n = 15774) | |
| Age (yr) | 55.91 (15.83), (56, 17-99) | 56.04 (16.43), (57, 17-108) |
| 17-30 | 338 (6.43) | 1014 (6.43) |
| 30-40 | 633 (12.04) | 1899 (12.04) |
| 40-50 | 929 (17.67) | 2787 (17.67) |
| 50-60 | 1215 (23.11) | 3645 (23.11) |
| 60-70 | 1124 (21.38) | 3372 (21.38) |
| 70-80 | 731 (13.9) | 2193 (13.9) |
| 80+ | 288 (5.48) | 864 (5.48) |
| Gender | ||
| Female | 2866 (54.51) | 8598 (54.51) |
| Male | 2392 (45.49) | 7176 (45.49) |
| Country of birth | ||
| Africa and Middle East | 273 (5.19) | 819 (5.19) |
| America | 73 (1.39) | 219 (1.39) |
| Asia | 19 (0.36) | 57 (0.36) |
| Europe | 2334 (44.39) | 7002 (44.39) |
| Israel | 2425 (46.12) | 7275 (46.12) |
| Data N/A | 134 (2.55) | 402 (2.55) |
| Diagnosis/sampling year | ||
| 2001-2004 | 732 (13.92) | 2196 (13.92) |
| 2005-2008 | 1263 (24.02) | 3789 (24.02) |
| 2009-2012 | 1351 (25.69) | 4053 (25.69) |
| 2013-2015 | 1068 (20.31) | 3204 (20.31) |
| 2016-2018 | 844 (16.05) | 2532 (16.05) |
Table 2 Comparison between the number of platelets measurements and co-morbidities between cases with cirrhosis and controls, n (%)
| Cirrhosis | Control | OR | 95%CI | ||
| Low | Up | ||||
| Platelets measurements | 15.59 (14.36) | 10.69 (10.33) | 1.033 | 1.031 | 1.036 |
| Platelets measurements: 3-10 | 2510 (47.74) | 10482 (66.45) | 1 | ||
| 11-20 | 1409 (26.8) | 3395 (21.52) | 1.73 | 1.61 | 1.87 |
| 21+ | 1339 (25.47) | 1897 (12.03) | 2.95 | 2.72 | 3.20 |
| Diabetes | 326 (6.2) | 847 (5.37) | 1.17 | 1.02 | 1.33 |
| HTN | 170 (3.23) | 447 (2.83) | 1.15 | 0.96 | 1.37 |
| CKD | 390 (7.42) | 961 (6.01) | 1.24 | 1.09 | 1.4 |
| Dyslipidemia | 915 (17.4) | 2843 (18.02) | 0.96 | 0.88 | 1.04 |
| Smoking | 1563 (29.73) | 3470 (22) | 1.5 | 1.398 | 1.609 |
Table 3 Distribution of cirrhosis etiology and complications among cirrhotic patients (n = 5258)
| Frequency | Percent | |
| Etiology | ||
| ALD | 488 | 9.28 |
| Viral | 987 | 18.77 |
| Autoimmune | 159 | 3.02 |
| Wilson | 9 | 0.17 |
| NAFLD | 413 | 7.85 |
| Complications | ||
| Ascites | 450 | 8.56 |
| Varices | 551 | 10.48 |
| HE | 294 | 5.59 |
| HCC | 10 | 0.19 |
| SBP | 118 | 2.24 |
| Portal HTN | 511 | 9.72 |
| Splenomgally | 764 | 14.53 |
| PVT | 70 | 1.33 |
- Citation: Gotlieb N, Schwartz N, Zelber-Sagi S, Chodick G, Shalev V, Shibolet O. Longitudinal decrease in platelet counts as a surrogate marker of liver fibrosis. World J Gastroenterol 2020; 26(38): 5849-5862
- URL: https://www.wjgnet.com/1007-9327/full/v26/i38/5849.htm
- DOI: https://dx.doi.org/10.3748/wjg.v26.i38.5849
