Clinicopathological features of early gastric cancers arising in Helicobacter pylori uninfected patients

Table 1 Clinicopathological features of Helicobacter pylori uninfected early gastric cancers

	n = 30
mean age ± SD (yr)	59 ± 9
Gender, n
Male	19 (63.3%)
Female	11 (46.7%)
Location, n
Upper part	15 (50%)
Middle part	1 (3.3%)
Lower part	14 (46.7%)
Morphology, n
Protruded /flat	17 (56.7%)
Depressed	13 (43.3%)
Mean tumor diameter (range)	8 (2-98 mm)
Depth of invasion, n
M	24 (80%)
SM1	5 (16.7%)
SM2	1 (3.3%)
Histological type, n
Differentiated type	22 (73.3%)
Undifferentiated type	8 (26.7%)
Histological classification
Fundic grand type adenocarcinoma	7 (23.3%)
Foveolar type well differentiated adenocarcinoma	8 (26.7%)
Intestinal phenotype adenocarcinoma	7 (23.3%)
Pure signet ring call carcinoma	8 (26.7%)
Ulcerative finding, n
(-)	30 (100%)
(+)	0 (0%)
En-bloc resection, n	96.7%
R0+curative resection (cura A)	93.3%
Complication
Perforation	6.7%
Delayed perforation	0%
Delayed bleeding	0%

Table 2 Case series of Helicobacter pylori uninfected early gastric cancer in present study

Case	Classification	Sex	Age	Location	Morphology	Size	Depth	Histology	v/ly	RUT	UBT	HP-IgG
1	Fundic	m	55	U	0-IIc	6	sm1	tub1	0		+	+
2	Fundic	m	80	U	0-IIc	12	sm1	tub2 > tub1	0		+	+
3	Fundic	f	65	U	0-IIa	6	sm1	tub1,	0		+	+
4	Fundic	f	65	U	0-IIa	10	m	tub1	0	+	+	+
5	Fundic	m	69	U	0-IIa + IIc	8	sm1	tub1,	0		+	+
6	Fundic	m	62	U	0-IIa	13	sm2	tub1	0		+	+
7	Fundic	m	67	U	0-I	6	sm1	tub1	0		+	+
8	Foveolar	f	34	U	0-IIa	35	m	tub1	0		+	+
9	Foveolar	f	66	U	0-IIa	33	m	pap	0	+	+	+
10	Foveolar	m	63	U	0-IIa	55	m	tub1	0		+	+
11	Foveolar	f	69	U	0-IIa	98	m	tub1	0		+	+
12	Foveolar	f	51	U	0-IIa	28	m	tub1	0		+	+
13	Foveolar	m	72	U	0-IIa	63	m	tub1	0		+	+
14	Foveolar	m	64	U	0-IIa	42	m	tub1 > pap	0		+	+
15	Foveolar	f	50	U	0-IIa	2	m	tub1	0		+	+
16	Intestinal	m	66	L	0-IIc	9	m	tub1	0		+	+
17	Intestinal	m	49	L	0-IIc	5	m	tub1	0	+	+	+
18	Intestinal	f	65	L	0-IIa	3	m	tub1	0	+	+
19	Intestinal	f	61	L	0-IIc	5	m	tub1	0		+	+
20	Intestinal	f	43	L	0-IIc	3	m	tub1	0		+	+
21	Intestinal	m	48	L	0-IIa	7	m	tub1	0		+	+
22	Intestinal	f	52	L	0-IIa	5	m	tub1	0		+	+
23	Sig	m	58	L	0-IIc	4	m	sig	0	+	+
24	Sig	m	55	L	0-IIc	5	m	sig	0	+	+	+
25	Sig	m	65	M	0-IIc	5	m	sig	0		+	+
26	Sig	m	49	L	0-IIc	13	m	sig	0		+	+
27	Sig	m	53	L	0-IIc	4	m	sig	0		+	+
28	Sig	m	45	L	0-IIc	8	m	sig	0		+	+
29	Sig	m	46	L	0-IIb	12	m	sig	0		+	+
30	Sig	m	84	L	0-IIa	2	m	sig	0		+	+

Fundic: Fundic grand type adenocarcinoma; Foveolar: Foveolar type well differentiated adenocarcinoma; Intestinal: Intestinal phenotype adenocarcinoma; Sig: Pure signet ring cell carcinoma; v/ly: Lyphovascular invasion; RUT: Rapid urease test; UBT: Urease breath test.

Table 3 Mucus phenotype of Helicobacter pylori uninfected early gastric cancers

	MUC5AC	MUC6	CD10	MUC2
Fundic grand type adenocarcinoma	++	++	-	-
Foveolar type well differentiated adenocarcinoma	++	-	-	-
Intestinal phenotype adenocarcinoma	-~+	-~+	++	+~++
Pure signet ring cell carcinoma	++	++	-	-