Serum outperforms plasma in small extracellular vesicle microRNA biomarker studies of adenocarcinoma of the esophagus

Table 1 Top 20 abundant microRNAs expressed in plasma and serum small extracellular vesicle preparations

Rank	Plasma miRNA	Relative levels ± SD (× 105)	Serum miRNA	Relative levels ± SD (× 105)
1	hsa-miR-223-3p1	521.3 ± 310.6	hsa-miR-92a-3p1	100.2 ± 178.0
2	hsa-miR-92a-3p1	268.7 ± 188.5	hsa-miR-223-3p1	53.8 ± 24.8
3	hsa-miR-20a-5p1	89.8 ± 38.3	hsa-miR-451a1	17.6 ± 22.1
4	hsa-miR-19b-3p1	83.2 ± 40.1	hsa-miR-19b-3p1	14.7 ± 15.8
5	hsa-miR-24-3p1	79.0 ± 44.7	hsa-miR-20a-5p1	14.6 ± 14.3
6	hsa-miR-30a-5p1	54.8 ± 31.1	hsa-miR-30a-5p1	9.4 ± 11.0
7	hsa-miR-451a1	43.3 ± 22.0	hsa-miR-320a-3p1	9.3 ± 13.5
8	hsa-miR-320a-3p1	40.1 ± 17.5	hsa-miR-328-3p1	9.1 ± 3.7
9	hsa-miR-484	36.7 ± 23.4	hsa-miR-24-3p1	7.2 ± 3.2
10	hsa-miR-17-5p1	27.2 ± 12.6	hsa-miR-1274b	6.4 ± 3.9
11	hsa-miR-106a-5p1	26.0 ± 11.7	RNU6-1	5.5 ± 4.0
12	hsa-miR-16-5p1	21.2 ± 20.8	hsa-miR-106a-5p1	5.4 ± 4.2
13	hsa-miR-328-3p1	19.2 ± 5.4	hsa-miR-16-5p1	5.1 ± 8.8
14	hsa-miR-130a-3p	17.5 ± 7.2	hsa-miR-17-5p1	5.0 ± 3.9
15	hsa-miR-30c-5p	17.1 ± 11.6	hsa-miR-150-5p1	4.0 ± 2.1
16	hsa-miR-146a-5p1	16.2 ± 12.0	hsa-miR-517a-3p	2.8 ± 2.4
17	hsa-miR-221-3p	13.4 ± 7.2	hsa-miR-30b-5p1	2.1 ± 1.2
18	hsa-miR-150-5p1	13.3 ± 8.5	hsa-miR-146a-5p1	1.8 ± 1.1
19	has-hsa-miR-30b-5p1	11.5 ± 6.6	hsa-miR-191-5p1	1.7 ± 0.9
20	hsa-miR-191-5p1	10.6 ± 5.9	hsa-miR-25-3p	1.6 ± 2.3

¹miRNAs were common between serum and plasma.