Dbx2 exhibits a tumor-promoting function in hepatocellular carcinoma cell lines via regulating Shh-Gli1 signaling

Table 1 Clinicopathological characteristics of hepatocellular carcinoma patients included in the study

Characteristic		n = 76	Proportion (%)
Gender
	Male	64	84.21
	Female	12	15.79
Age (yr)		Median age 56
	<60	52	68.42
	≥60	24	31.58
Differentiation
	Well	52	68.42
	Poor	24	31.58
Tumor size (cm)
	< 5	53	69.74
	≥ 5	23	30.26
Lymph node metastasis
	Yes	16	21.05
	No	60	78.95
HBV infection
	Yes	41	53.95
	No	35	46.05
HCV infection
	Yes	4	5.26
	No	72	94.74
Serum alpha-fetoprotein level (ng/mL)
	< 400	56	73.68
	≥ 400	20	26.32

Table 2 Correlation between developing brain homeobox 2 expression and characteristics of hepatocellular carcinoma n (%)

Characteristic		Dbx2 High (n = 29)	Dbx2 Low (n = 47)	P-value
Gender				0.038
	Male	28 (93.10)	36 (76.60)
	Female	1 (6.90)	11 (23.40)
Age (yr)		Median age 56		0.771
	< 60	18 (62.07)	72.34)
	> 60	11 (37.93)	13 (27.66)
Differentiation				0.905
	Well	19 (65.52)	33 (70.21)
	Poor	10 (34.48)	14 (29.79)
Tumor size (cm)				0.025
	< 5	16 (55.17)	37 (78.72)
	≥ 5	13 (44.83)	10 (21.28)
Lymph node metastasis				0.162
	Yes	10 (34.48)	11 (23.40)
	No	19 (65.52)	36 (76.60)
HBV infection				0.572
	Yes	16 (55.17)	19 (40.43)
	No	13 (44.83)	28 (59.57)
HCV infection				0.654
	Yes	2 (6.90)	2 (4.26)
	No	27 (93.10)	45 (95.74)
Serum alpha-fetoprotein level (ng/mL)				0.180
	< 400	20 (68.97)	36 (76.60)
	≥ 400	9 (31.03)	11 (23.40)