Inositol 1,4,5-trisphosphate receptor in the liver: Expression and function

doi:10.3748/wjg.v25.i44.6483

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Nov 28, 2019 (publication date) through Nov 29, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 28, 2019; 25(44): 6483-6494
Published online Nov 28, 2019. doi: 10.3748/wjg.v25.i44.6483

Table 1 Functions of inositol 1,4,5-trisphosphate receptor isoforms in hepatocytes and cholangiocytes

ITPR isoform	Cell type	Function	Ref.
ITPR1	Hepatocytes	Glucose secretion	[64]
		Lipid metabolism	[63,65]
		Liver regeneration	[66,67]
	Cholangiocytes	Bicarbonate secretion	[12,61]
ITPR2	Hepatocytes	Organic anion secretion	[6,62,69]
	Hepatocytes	Liver regeneration	[13,71]
	Cholangiocytes	bicarbonate secretion	[12,61]
ITPR3	Hepatocytes	Physiologically absent	[6]
	Hepatocytes	Proliferation and survival of hepatocellular carcinoma	[74]
	Cholangiocytes	Bicarbonate secretion	[12,61]
	Cholangiocytes	Proliferation, migration, and survival of cholangiocarcinoma	[82]

ITPR: Inositol 1,4,5-trisphosphate receptor; ITPR1: ITPR isoform 1; ITPR2: ITPR isoform 2; ITPR3: ITPR isoform 3.

Citation: Lemos FO, Florentino RM, Lima Filho ACM, Santos MLD, Leite MF. Inositol 1,4,5-trisphosphate receptor in the liver: Expression and function. World J Gastroenterol 2019; 25(44): 6483-6494
URL: https://www.wjgnet.com/1007-9327/full/v25/i44/6483.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i44.6483