Adenoma and advanced neoplasia detection rates increase from 45 years of age

Table 1 Multivariate analysis of the adenoma detection rate in the whole population (n = 6027)

Variable	Univariate analysis		Multivariate analysis
	Odds ratio	P	Odds ratio	95%CI	P value
Male gender	1.8	10-5	1.7	1.5-1.9	10-5
Age > 45 yr	1.5	10-5	1.3	1.1-1.6	0.0005
Good prep	1.3	0.02
Screening	REF		REF
Family history	0.60	0.0006	0.65	0.5-0.0	0.004
Personal history	1.5	0.001	1.53	1.2-2.0	0.002
FIT +	2.7	10-5	2.7	1.9-3.6	10-5
Digestive symptoms	0.6	0.0005	0.7	0.5-0.9	0.02
Other indications	0.36	10-5	0.4	0.3-0.5	10-5

FIT: Fecal immunochemical test.

Table 2 Comparison of patients’ characteristics, colonoscopy data and detection rates in patients aged 45-49 years and over 50 years n (%)

		45-49 yr (n = 515)	≥ 50 yeas (n = 4436)	P value
Gender, male/female, n		236/279	2028/2408	0.98
Indications for colonoscopy
Patients without symptoms		268 (52)	3,006 (68)	< 0.001
High risk
	Personal or family history of polyps	204 (39.6)	2082 (46.9)	0.002
Average risk		311 (60.4)	2354 (53)	< 0.001
	Digestive symptoms	247 (48)	1430 (32.2)
	Other	64 (12.4)	924 (20.8)
Colonoscopy data
Sub-optimal preparation		30 (5.8)	275 (6.2)	0.84
Mean number of polyps		0.47	0.78	-
Median withdrawal time, s		452	471	0.49
Histological data
Polyp detection rate, %		29.1	40	< 0.001
Adenoma detection rate, %		21.2	34.6	< 0.001
Serrated polyp detection rate, %		11.7	10.1	0.32
Advanced neoplasia detection rate, %		6.4	11.8	< 0.001