Up-regulated Wnt1-inducible signaling pathway protein 1 correlates with poor prognosis and drug resistance by reducing DNA repair in gastric cancer

Table 1 Correlation between Wnt1-inducible signaling pathway protein 1 expression and clinicopathological variables in gastric cancer patients

Variable		Number	Low expression (n = 67)	High expression (n = 83)	P value
Age (yr)
	< 60	63	25	38	0.299
	≥ 60	87	42	45
Gender
	Male	69	30	39	0.789
	Female	81	37	44
Tumor differentiation
	Well/moderate	80	33	47	0.372
	Poor	70	34	36
T stage
	T1-T2	81	45	36	0.003
	T3-T4	69	22	47
N stage
	N0	39	16	23	0.598
	N1-N3	111	51	60
TNM stage
	I-II	109	49	60	0.909
	III	41	18	23
Chemotherapy outcome
	CR/PR	67	38	29	0.019
	SD/PD	83	30	53

CR: Complete response; PR: Partial response; SD: Stable disease; PD: Progressive disease; TNM: Tumor node metastasis.

Table 2 Univariate and multivariate analyses of prognostic factors for gastric cancer

Variable	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Age (> 60 vs < 60)	1.003 (0.618-1.628)	0.991
Gender (Female vs Male)	0.874 (0.639-1.195)	0.400
Differentiation (Poorly vs Well/moderately)	1.236 (0.760-2.009)	0. 393
TNM stage (III vs I-II)	3.714 (2.261-6.102)	< 0.001	2.676 (1.236-5.793)	0.013
T stage (T3-T4 vs T2-T1)	1.931 (1.178-3.165)	0.009
N stage (N1-N3 vs N0)	2.666 (1.599-4.448)	< 0.001	2.089 (1.169-3.732)	0.013
Chemotherapy outcome (SD/PD vs CR/PR)	3.254 (1.885-5.616)	< 0.001
WISP1 (High vs Low)	2.341 (1.385-3.956)	0.0019	2.180 (1.187-4.003)	0.012

CR: Complete response; PR: Partial response; SD: Stable disease; PD: Progressive disease; TNM: Tumor-node-metastasis; CI: Confidence interval; HR: Hazard ratio.