Biomarkers and subtypes of deranged lipid metabolism in non-alcoholic fatty liver disease

doi:10.3748/wjg.v25.i24.3009

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 28, 2019; 25(24): 3009-3020
Published online Jun 28, 2019. doi: 10.3748/wjg.v25.i24.3009

Table 1 Nonalcoholic fatty liver disease subtype classification

NAFLD subtype	Characteristics	Mouse model-based classification	Treatments tested
M-Subtype	Increased fatty acid uptake.	Mat1a KO[37]	SAMe
	Low liver glutathione and SAMe content.	0.1MCD[59]	Aramchol
	Low liver glutathione and SAMe content.
	Reduced synthesis of PC-PUFA.
	Abnormal VLDL-TG assembly and export.
Non-M-Subtype	Increased DNL.	Ldlr KO/HFD[68]	Obeticholic acid
	Normal hepatic SAMe levels.
	Normal VLDL-TG secretion.
	High serum levels of cholesterol and TG.

NAFLD: Nonalcoholic fatty liver disease; SAMe: S-adenosylmethionine; PC-PUFA: Phosphatidylcholines containing polyunsaturated fatty acids; VLDL-TG: Very low-density lipoprotein-triglycerides; DNL: de novo lipogenesis; KO: Knockout; MCD: Methionine and choline deficient.

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Citation: Mato JM, Alonso C, Noureddin M, Lu SC. Biomarkers and subtypes of deranged lipid metabolism in non-alcoholic fatty liver disease. World J Gastroenterol 2019; 25(24): 3009-3020
URL: https://www.wjgnet.com/1007-9327/full/v25/i24/3009.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i24.3009