Comparison of renal safety of tenofovir and entecavir in patients with chronic hepatitis B: Systematic review with meta-analysis

Table 1 Main characteristics of included studies

Author, year country	Design	Duration (mo)	Cirrhosis (%)	Patients (n)	Age (mean)	Sex (M/F)	HBV_DNA	End point
				TDF	TDF	TDF
				ETV	ETV	ETV	(log10 IU/Ml)
Ha et al[14] 2015 United States	Matched case-cohort	24(18-66)	9.20%	103	43.5	65/38	5.3 ± 1.5	RMSRC Decrease in eGFR 20%
				103	43.8	65/38	6.15 ± 1.9
Lee et al[15] 2015 South Korea	Prospective	≥ 6	NA	258	66.4	173/85	6.40 ± 1.31	NA
				308	50.5	190/118	6.72 ± 1.22
Yu et al[16] 2015 South Korea	Retrospective	8.45/18.7	50%	49	48.8	22/27	6.98 ± 1.55	Creatinine ≥ 0.3 mg/dL or 1.5 times above baseline
				58	51.7	33/25	7.05 ± 1.33
Park et al[20] 2017 South Korea	Retrospective	24	100%	73	56.4	45/28	5.4 ± 1.3	Serum creatinine increase > 0.2 mg/dLeGFR < 60 mL/min (CKD-EPI)Decrease in eGFR > 20% (CKD-EPI)
				162	55.6	110/52	5.6 ± 1.6
Koklu et al [24] 2015 Turkey	Prospective	24	34%	273	47.7	183/90	6.54 ± 1.74	Shift from ≥ 90 to 60-89 mL/min per 1.73 m2> 25% increased creatinine
				282	49.9	197/85	6.69 ± 1.79
Idilman et al[25] 2015 Turkey	Retro-prospective	36 (6-78)	39%	172	47 (15-79)	NA	5.97 ± 1.72	Serum creatinine > 0.5 mg/dL from baseline, eGFR < 50 mL/min
				183		NA
Koksal 2016 et al[23] Turkey	Prospective	≥ 24	NA	44	36 (29-43.7)	19/25	6.8 ± 1.0
				32	40 (27.2-46.5)	17/15	7.0 ± 1.2
Lopez et al [22] 2016 Spain	Retrospective	12	33.90%	32	50.2	25/7	1127.4 (19-2463,121)	eGFR < 60 mL/min per 1.73 m2 eGFR reduction > 25%Increase in creatinine > 1.4 mg/dl
				32	49.2	23/9	29311.4 (376.2-4660,135)
Tsai et al[21] 2016 Taiwan	Retro-prospective	≥ 24	52%	37	56.6	32/5	6.3 ± 1.3	Change of eGFR by 25%
				62	55.2	46/16	6.4 ± 1.2

TDF: Tenofovir; ETV: Entecavir; HBV: Hepatitis B virus; CHB: Chronic hepatitis B; M: Male; F: Female; NA: Not available; eGFR: Estimated glomerular filtration rate; HTN: Hypertension; DM: Diabetes mellitus; HCC: Hepatocellular carcinoma; MDRD: Modification of diet in renal disease; CKD-EPI: Chronic kidney disease epidemiology collaboration; CTx: Chemotherapy; OT: Organ transplantation; RMSRC: Reclassified to a more severe renal classification.