Expression of genes that control core fucosylation in hepatocellular carcinoma: Systematic review

Table 1 Literature citations to core fucosylation related genes and hepatocellular carcinoma

Gene symbol	Citations (gene)	Citations (protein name)	EC2	Uniprot ID	Uniprot citations
FPGT	0	0	2.7.7.30	O14772	7
FUK	0	0	2.7.1.52	Q8NOW3	4
FUT8	16	17	2.4.1.68	Q9BYC5	15
GMDS	2	41	4.2.1.47	O60547	25
SLC35C1	1	1	NA	Q96A29	13
TSTA3	4	13	1.1.1.271	Q13630	12

¹The protein name searched was mannose dehydratase;

²Enzyme commission; NA: Not applicable.

Table 2 Summary of mutational and expression data for core fucose related genes

	GMDS	TSTA3	FPGT	FUK	FUT8	SLC35C1
Total changes (%)	13	29	7	5	6	6
mRNA up	27	78	15	13	21	18
mRNA down	0	0	6	3	0	0
Non-synonymous or truncating mutation	0	0	2	0	1	2
Copy increase	23	58	1	2	3	2
Deep deletion	3	0	1	0	2	0

Table 3 Genes with expression patterns that correlate positively with the GMDS gene

Gene symbol	Cytoband	Spearman score
FLOT1	6p21.3	0.43
SLC39A7	6p21.3	0.38
FKBPL	6p21.3	0.36
SERPINB1	6p25	0.36
PSMG4	6p25.2	0.36
IFT43	14q24.3	0.36
VARS	6p21.3	0.36
KDELR1	19q13.3	0.35
CLIC1	6p21.3	0.35
TRIM27	6p22	0.35

Table 4 Genes with expression patterns that correlate positively with the TSTA3 gene

Gene symbol	Cytoband	Spearman score
SHARPIN	8q24.3	0.67
HGH1	8q24.3	0.68
FBXL6	8q24.3	0.68
EXOSC4	8q24.3	0.65
VPS28	8q24.3	0.65
HSF1	8q24.3	0.63
COMMD5	8q24.3	0.62
CYC1	8q24.3	0.62
MAF1	8q24.3	0.61
GPAA1	8q24.3	0.61

Table 5 Genes with expression patterns that correlate positively with the FUK gene

Gene symbol	Cytoband	Spearman score
TMEM208	16q22.1	0.65
COG4	16q22.1	0.65
PRMT7	16q22.1	0.61
PSMD7	16q22.3	0.60
TRADD	16q22	0.59
WWP2	16q22.1	0.59
MTHFSD	16q24.1	0.58
CHMP1A	16q24.3	0.58
TCF25	16q24.3	0.58
ATP6V0D1	16q22.1	0.58

Table 6 Genes with expression patterns that correlate positively with the FPGT gene

Gene symbol	Cytoband	Spearman score
IPP	1p34-p32	0.7
ZZZ3	1p31.1	0.63
EPS15	1p32	0.62
PKN2	1p22.2	0.62
ATG4C	1p31.3	0.6
GPBP1L1	1p34.1	0.59
LEPROT	1p31.3	0.59
PIGK	1p31.1	0.59
LRRC40	1p31.1	0.58
FAM73A	1p31.1	0.58

Table 7 Genes with expression patterns that correlate positively with the SLC35C1 gene

Gene symbol	Cytoband	Spearman score
LRG1	19p13.3	0.56
DKFZP779M0652	11p11.2	0.55
NAMPT	7q22.3	0.55
CRP	1q23.2	0.52
FNDC4	2p23.3	0.51
GLRX	5q14	0.51
LBP	20q11.23	0.51
TGM2	20q12	0.49
MGAT4B	5q35	0.48
CREB3L3	19p13.3	0.48

Table 8 Genes with expression patterns that correlate positively with the FUT8 gene

Gene symbol	Cytoband	Spearman score
IQGAP1	15q26.1	0.71
HACD4	9p21.3	0.71
APOBEC3C	22q13.1	0.69
ELF4	Xq26	0.68
HAPLN3	15q26.1	0.68
TRERF1	6p21.1-p12.1	0.68
WIPF1	2q31.1	0.67
RAB31	18p11.3	0.66
FMNL3	12q13.12	0.66
SYT11	1q21.2	0.66