Human antigen R mediated post-transcriptional regulation of inhibitors of apoptosis proteins in pancreatic cancer

Table 1 Characteristics of the patients after pancreatoduodenectomy for pancreatic cancer n (%)

Variable	No. of cases (n = 61)
Gender
Male	26 (42.6)
Female	35 (57.4)
Age, yr (median)	68
T stage
T1	3 (4.9)
T2	3 (4.9)
T3	55 (90.2)
T4	0 (0)
N status
N0	11 (18.0)
N1	50 (82.0)
Lymphatic invasion
L0	11 (18.0)
L1	50 (82.0)
Microvascular invasion
V0	12 (19.7)
V1	49 (80.3)
Perineural invasion
No	9 (14.8)
Yes	52 (85.2)
Differentiation grade
G1	9 (14.8)
G2	35 (57.4)
G3	16 (26.2)
G4	1 (1.6)
Resection status
R0	56 (91.8)
R1	5 (8.2)
Median survival (mo)	23.10

Table 2 Univariate analysis of histopathological features (log-rank)

Variable		P value
Resection status	R0/R1-R2	0.005
T stage	T1-T2/T3-T4	0.146
Lymph-nodes	N0/N1	0.046
Tumor differentiation	G1-G2/G3-G4	0.027
Perineural invasion	Yes/No	0.010
Micro-vessel infiltration	Yes/No	0.073
Lymphatic invasion	Yes/No	0.039
IAP1 expression	High/low	0.022
IAP2 expression	High/low	0.624

IAP1: Inhibitor of apoptosis protein 1; IAP2: Inhibitor of apoptosis protein 2.

Table 3 Multivariate analysis for overall survival

Variables	Overall Survival
	HR	95%CI	P value
Tumor differentiation, G1-G2/G3-G4	2.73	1.17-6.37	0.02
Resection status, R0/R1-R2	2.87	1.31-6.29	0.008
IAP1 expression, high/low	5.51	1.95-15.59	0.001

CI: Confidence interval; HR: Hazard ratio; IAP1: Inhibitor of apoptosis protein 1.