Clinical value of preoperative methylated septin 9 in Chinese colorectal cancer patients

Table 1 Clinicopathological characteristics based on methylated septin 9 status in 300 colorectal cancer patients

Parameter		Positive group (%)	Negative group (%)	P
Gender	Male	84 (28.0)	81 (27.0)	0.585
	Female	73 (24.3)	62 (20.7)
Age	≤ 50 yr	45 (15.0)	60 (20.0)	0.016
	> 50 yr	112 (37.3)	83 (27.7)
UICC stage	I	9 (3.0)	20 (6.7)	0.020
	II	46 (15.3)	32 (10.7)
	III	62 (20.6)	71 (23.7)
	IV	13 (4.3)	6 (2.0)
	Unknown	27 (9.0)	14 (4.7)
Histologic grade	Low level	115 (38.3)	103 (34.3)	0.972
	High level	18 (6.0)	17 (5.7)
	Not recorded	24 (8.0)	23 (7.7)
Primary tumor (T) category	T1	2 (0. 7)	3 (1.0)	0.002
	T2	15 (5.0)	23 (7.7)
	T3	70 (23.3)	67 (22.3)
	T4	40 (13.3)	34 (11.3)
	Not recorded	30 (10.0)	16 (5.3)
Regional node (N) category	N0	57 (19.0)	23 (7.7)	0.852
	N1	32 (10.7)	67 (22.3)
	N2	37 (12.3)	34 (11.3)
	Not recorded	31 (10.3)	16 (5.3)
Distant metastasis (M)	Absent	141 (47.0)	137 (45.7)	0.015
	Present	16 (5.3)	6 (2.0)
Lymphatic invasion (L)	Absent	58 (19.3)	60 (20.0)	0.217
	Present	51 (17.0)	52 (17.3)
	Not recorded	48 (16.0)	31 (10.3)
Lymph nodal status	No node involved	51 (17.0)	52 (17.3)	0.048
	1-3 lymph node involved	27 (9.0)	40 (13.3)
	> 4 lymph node involved	31 (10.3)	20 (6.7)
	Not recorded	48 (16)	31 (10.3)
Vascular invasion (V)	Absent	36 (12.0)	31 (10.3)	0.278
	Present	70 (23.3)	76 (25.3)
	Not recorded	51 (17.0)	36 (12.0)
Tumor sitea	Left colon	44 (14.7)	31 (10.3)	0.022
	Right colon	27 (9.0)	11 (3.7)
	Rectum	74 (24.7)	86 (28.6)
	Unable to distinguish	12 (4.0)	15 (5.0)

^aRight colon includes cecum through transverse colon, whereas left colon includes splenic flexure, descending colon, and sigmoid colon. Clinicopathological characteristics between positive group and negative group were analyzed using χ² test. UICC: Union for International Cancer Control.