Functional role of long non-coding RNA CASC19/miR-140-5p/CEMIP axis in colorectal cancer progression in vitro

Table 1 Associations of cancer susceptibility 19 expression with clinicopathologic features of patients with colorectal cancer

Feature	Total (n = 52)	CASC19 expression		P-value
		High	Low
Gender
Male	25	10	15	0.483
Female	27	12	15
Age, yr
≤ 60	13	5	8	0.503
> 60	39	17	22
Tumor size
≤ 5 cm	22	9	13	0.379
> 5 cm	30	13	17
TNM stage
I-II	23	6	17	0.019a
III-IV	29	16	13
Local invasion
T1 + T2	9	4	5	0.585
T3 + T4	43	18	25
Lymphatic metastasis
Yes	22	14	8	0.008b
No	30	8	22
Liver metastasis
Yes	18	13	5	0.002b
No	34	9	25

^aP < 0.05.

^bP < 0.01.

CASC19: Cancer susceptibility 19; CRC: Colorectal cancer.

Table 2 Univariate and multivariate analyses of variables influencing survival of 52 patients with colorectal cancer

Variable	Univariate analysis	Multivariate analysis
	P-value	Exp(B)	95%CI	P-value
CASC19	< 0.001b	8.893	2.596-30.464	0.001a
Age, yr	0.202	-	-	-
Gender	0.719	-	-	-
Tumor size	0.376	-	-	-
TNM stage	0.025a	-	-	0.407
Local invasion	0.011a	-	-	0.322
Lymphatic metastasis	< 0.001b	11.395	3.201-40.565	< 0.001b
Local invasion and liver metastasis	< 0.001b	7.274	2.382-22.211	< 0.001b

^aP < 0.05.

^bP < 0.01.

CASC19: Cancer susceptibility 19; CRC: Colorectal cancer; Exp(B): The exponent of B; CI: Confidence interval.