Analysis of hepatitis B virus preS1 variability and prevalence of the rs2296651 polymorphism in a Spanish population

Table 1 Demographic characteristics of the 246 patients included

	Group A, CHB (n = 41)	Group B, Resolvers (n = 100)	Group C, Controls (n = 105)	P value1
Gender, n males (%)	22 (54)	54 (54)	54 (51)	NS
Age, yr, mean ± SD	54.8 ± 19.1	62.1 ± 13.0	60.3 ± 13.5	NS
Origin, n (%)
Caucasian	30 (73)	100 (100)	100 (100)	-
Asian	5 (12)	0 (0)	0 (0)	-
Sub-Saharan	6 (15)	0 (0)	0 (0)	-

¹P-value χ² test for gender (qualitative variable), and t-test for age (quantitative variable). CHB: Chronic hepatitis B; NS: Not statistically significant.

Table 2 Individual demographic, biochemical and virological characteristics of the 18 patients from group A (chronic hepatitis B patients) in whom the preS1 region was analyzed

ID	Gender	Age	Origin	HBV Genotype1	HBV DNA (logIU/mL)	ALT (IU/L)	HBeAg
1	Female	68	Caucasian	D	5.0	29	Negative
2	Male	55	Caucasian	A	5.8	46	Negative
3	Female	40	Caucasian	D	4.2	29	Negative
4	Male	47	Caucasian	F	5.8	88	Negative
5	Female	47	Caucasian	D	6.3	170	Negative
6	Female	28	Caucasian	D	5.4	22	Negative
7	Male	28	Asian	C	> 8	94	Positive
8	Female	41	Caucasian	A	4.7	18	Negative
9	Male	39	Caucasian	D	5.0	29	Negative
10	Male	45	Caucasian	F	> 8	51	Positive
11	Female	35	Asian	C	> 8	56	Positive
12	Female	46	Caucasian	H	5.3	23	Negative
13	Male	37	Sub-Saharan	E	4.3	37	Negative
14	Female	54	Caucasian	A	4.3	21	Negative
15	Female	36	Asian	C	> 8	19	Positive
16	Female	20	Sub-Saharan	E	5.1	22	Positive
17	Male	73	Caucasian	B	> 8	221	Negative
18	Male	49	Asian	B	5.6	181	Negative

¹HBV genotype determined by Sanger sequencing of the preS1 region (the same region as was analyzed by next-generation sequencing). ALT: Alanine aminotransferase; HBV: Hepatitis B virus; HBeAg: Hepatitis B e antigen.