Wang BG, Xu Q, Lv Z, Fang XX, Ding HX, Wen J, Yuan Y. Association of twelve polymorphisms in three onco-lncRNA genes with hepatocellular cancer risk and prognosis: A case-control study. World J Gastroenterol 2018; 24(23): 2482-2490 [PMID: 29930469 DOI: 10.3748/wjg.v24.i23.2482]
Corresponding Author of This Article
Yuan Yuan, MD, PhD, Professor, Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University, No.155 NanjingBei Street, Heping District, Shenyang 110001, Liaoning Province, China. yuanyuan@cmu.edu.cn
Research Domain of This Article
Biochemistry & Molecular Biology
Article-Type of This Article
Case Control Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Table 3 The two-way interaction of HOTTIP rs17501292-MALAT1 rs619586 polymorphisms in the risk of hepatocellular cancer
Variables
MALAT1 rs619586
AA
AG + GG
HCC vs CON (n = 335 vs 572)
HOTTIP rs17501292
TT
Case/control
372/617
78/107
OR (95%CI)
1
1.21(0.88-1.66)
TG + GG
Case/control
61/55
6/15
OR (95%CI)
1.84 (1.25-2.71)
0.66 (0.26-1.73)
Pinteraction = 0.028, OR (95%CI) = 0.30 (0.10-0.88)
Table 4 Univariate proportional hazard analysis stratified by host characteristics for the association of lncRNA polymorphisms and hepatocellular cancer n (%)
Gene
SNP
Stratified
Stratified factors
Genotype
HCC
Death
MST (M)
P value
Hazard ratio (95%CI)
HOTTIP
rs3807598
n = 136
HBV
Positive
CC
30 (22.06)
12
90.0
1 (reference)
CG
73 (53.68)
23
90.1b
0.391
0.74 (0.37-1.48)
GG
33 (24.26)
11
64.1b
0.680
0.84 (0.37-1.91)
n = 31
Negative
CC
10 (32.26)
7
21.0
1 (reference)
CG
13 (41.94)
4
41.8b
0.374
0.60 (0.16-1.97)
GG
8 (25.80)
1
70.3b
0.049
0.12 (0.02-0.99)
n = 285
MALAT1
rs591291
n = 286
Gender
Male
CC
98 (34.27)
39
48.0
1 (reference)
TC
146 (51.05)
56
56.0
0.865
0.97 (0.64-1.45)
TT
42 (14.68)
19
47.0
0.678
1.12 (0.65-1.94)
n = 64
Female
CC
22 (34.38)
13
32.0
1 (reference)
TC
37 (57.81)
9
56.0
0.022
0.37 (0.16-0.87)
TT
5 (7.81)
0
NA
0.286
0.04 (0.00-16.09)
n = 139
HBV
Positive
CC
54 (38.85)
18
69.0
1 (reference)
TC
69 (49.64)
21
92.1b
0.816
0.93 (0.49-1.74)
TT
16 (11.51)
7
90.0
0.965
0.98 (0.41-2.35)
n = 31
Negative
CC
8 (25.81)
5
6.0
1 (reference)
TC
16 (51.61)
4
27.0
0.042
0.25 (0.07-0.95)
TT
7 (22.58)
3
21.0
0.215
0.40 (0.09-1.71)
Table 5 Differences of lncRNA gene mRNA levels in different genotypes in hepatocellular cancer and non-cancer tissues
The effect of HOTTIP rs17501292 genotypes to HOTTIP mRNA expression
TT
10
12.32 ± 4.06
1 (0.60, 16.68)
Ref.
25
11.84 ± 3.87
1.39 (0.10, 20.39)
Ref.
TG
1
NA
NA
NA
2
15.30 ± 1.65
NA
0.735
GG
0
NA
NA
NA
0
NA
NA
NA
The effect of HOTTIP rs2067087 genotypes to HOTTIP mRNA expression
GG
2
8.64 ± 2.06
1 (0.24, 4.17)
Ref.
5
11.66 ± 1.43
1 (0.37, 2.69)
Ref.
GC
5
12.25 ± 4.17
0.13 (0.01, 1.23)
0.253
13
11.85 ± 3.53
0.88 (0.08, 10.13)
0.101
CC
4
13.70 ± 3.86
0.03 (0.00, 0.86)
0.453
8
12.23 ± 5.42
0.67 (0.02, 28.84)
0.444
The effect of HOTTIP rs17427960 genotypes to HOTTIP mRNA expression
CC
2
8.64 ± 2.06
1 (0.24, 4.17)
Ref.
6
12.47 ± 2.34
1 (0.20, 5.06)
Ref.
CA
5
11.55 ± 3.21
0.13 (0.01, 1.15)
0.254
13
11.88 ± 3.72
2.13 (0.04, 125.37)
0.063
AA
3
13.56 ± 4.71
0.03 (0.00, 0.86)
0.465
6
11.38 ± 5.88
1.51 (0.11, 19.84)
0.348
The effect of MALAT1 rs4102217 genotypes to MALAT1 mRNA expression
GG
52
-2.25 ± 4.40
1 (0.05, 21.11)
Ref.
51
-0.98 ± 4.88
1 (0.03, 29.45)
Ref.
GC
16
-3.76 ± 3.60
2.85 (0.23, 34.54)
0.404
16
-2.79 ± 4.55
3.51 (0.15, 82.14)
0.742
CC
NA
NA
NA
NA
1
NA
NA
NA
Citation: Wang BG, Xu Q, Lv Z, Fang XX, Ding HX, Wen J, Yuan Y. Association of twelve polymorphisms in three onco-lncRNA genes with hepatocellular cancer risk and prognosis: A case-control study. World J Gastroenterol 2018; 24(23): 2482-2490