Copyright
©The Author(s) 2018.
World J Gastroenterol. May 28, 2018; 24(20): 2181-2190
Published online May 28, 2018. doi: 10.3748/wjg.v24.i20.2181
Published online May 28, 2018. doi: 10.3748/wjg.v24.i20.2181
Table 1 Correlation of cytoplasmic indoleamine-2,3-dioxygenase 1 expression with colorectal cancer clinicopathologic parameters
Characteristic | Total | Low IDO1 | High IDO1 | P-value |
Sex | 0.074 | |||
Male | 52 | 22 (42.3) | 30 (57.7) | |
Female | 43 | 27 (62.8) | 16 (37.2) | |
Age in yr | 0.65 | |||
≥ 60 | 30 | 17 (56.7) | 13 (43.3) | |
< 60 | 65 | 32 (49.2) | 33 (50.8) | |
Cancers | 0.93 | |||
Colon | 46 | 24 (52.2) | 22 (47.8) | |
Rectum | 49 | 25 (51.0) | 24 (49.0) | |
BMI | 0.16 | |||
≥ 25 | 20 | 7 (35.0) | 13 (65.0) | |
< 25 | 75 | 42 (56.0) | 33 (44.0) | |
Tumor differentiation | 0.47 | |||
Moderate and poor | 78 | 42 (54.5) | 35 (45.5) | |
Well | 17 | 7 (41.2) | 10 (58.8) | |
Colon cancer stage | 0.52 | |||
3 | 20 | 12 (60.0) | 8 (40.0) | |
2 | 26 | 12 (46.2) | 14 (53.8) | |
T stage | 0.69 | |||
4 | 29 | 14 (48.3) | 15 (51.7) | |
2/3 | 17 | 10 (58.8) | 7 (41.2) | |
N stage | 0.96 | |||
1/2 | 20 | 11 (55.0) | 9 (45.0) | |
0 | 26 | 13 (50.0) | 13 (50.0) | |
Rectum cancer stage | 0.67 | |||
3 | 24 | 11(45.8) | 13 (54.2) | |
2 | 25 | 14 (46.0) | 11 (44.0) | |
T stage | 0.68 | |||
4 | 22 | 12 (55.6) | 10 (45.4) | |
2/3 | 27 | 12 (44.4) | 15 (55.6) | |
N stage | 0.88 | |||
1/2 | 24 | 12 (50.0) | 12 (50.0) | |
0 | 25 | 13 (52.0) | 12 (48.0) | |
CEA in ng/mL | 0.45 | |||
> 5 | 42 | 24 (57.1) | 18 (42.9) | |
≤ 5 | 53 | 25 (47.2) | 28 (42.8) | |
CA19-9 in U/mL | 0.22 | |||
> 37 | 17 | 6 (35.3) | 11 (64.7) | |
≤ 37 | 78 | 43 (55.1) | 35 (44.9) | |
CD3 TILs | 0.27 | |||
High | 36 | 22 (61.1) | 14 (38.9) | |
Low | 59 | 28 (47.5) | 31 (42.5) | |
CD8 TILs | 0.96 | |||
High | 22 | 12 (54.5) | 10 (45.5) | |
Low | 73 | 38 (52.5) | 35 (47.5) | |
COX2 | 0.92 | |||
High | 48 | 26 (54.2) | 22 (45.8) | |
Low | 47 | 24 (51.1) | 23 (48.9) | |
Treatment group | 0.58 | |||
Celecoxib | 44 | 25 (56.8) | 19 (43.2) | |
Non-celecoxib | 51 | 25 (49.0) | 26 (51.0) |
Table 2 Correlation of nuclear indoleamine-2,3-dioxygenase 1 expression with colorectal cancer clinicopathologic parameters
Characteristic | Total | Low IDO1 | High IDO1 | P-value |
Sex | 0.70 | |||
Male | 51 | 39 (76.5) | 12 (33.5) | |
Female | 44 | 36 (81.8) | 8 (19.2) | |
Age in yr | 0.92 | |||
> 60 | 30 | 24 (80.0) | 6 (20.0) | |
≤ 60 | 65 | 51 (78.5) | 14 (21.5) | |
Cancers | 0.52 | |||
Colon | 46 | 38 (82.6) | 18 (17.4) | |
Rectum | 49 | 37 (75.5) | 12 (24.5) | |
BMI | < 0.001 | |||
> 25 | 20 | 9 (45.0) | 11 (55.0) | |
≤ 25 | 75 | 66 (88.0) | 9 (12.0) | |
Tumor differentiation | 0.87 | |||
Moderate and poor | 78 | 60 (76.9) | 18 (23.1) | |
Well | 17 | 14 (82.3) | 3 (17.7) | |
Conlon cancer stage | 0.98 | |||
3 | 20 | 17 (85.0) | 3 (15.0) | |
2 | 26 | 21 (80.8) | 5 (19.2) | |
T stage | 0.71 | |||
4 | 29 | 23 (19.3) | 6 (20.7) | |
2/3 | 17 | 15 (88.2.) | 2 (11.8) | |
N stage | 0.98 | |||
1/2 | 20 | 16 (80.0) | 4 (20.0) | |
0 | 26 | 22 (84.6) | 4 (15.4) | |
Rectum cancer stage | 0.44 | |||
3 | 24 | 17 (70.8) | 7 (29.2) | |
2 | 25 | 21 (84.0) | 4 (16.0) | |
T stage | 0.94 | |||
4 | 22 | 16 (72.7) | 6 (27.3) | |
2/3 | 27 | 21 (77.8) | 6 (22.2) | |
N stage | 0.28 | |||
1/2 | 24 | 16 (66.7) | 8 (33.3) | |
0 | 25 | 21(84.0) | 4 (16.0) | |
CEA in ng/mL | 0.37 | |||
> 5 | 42 | 35 (83.3) | 7 (16.7) | |
≤ 5 | 53 | 39 (73.6) | 14 (26.4) | |
CA19-9 in U/mL | 0.78 | |||
> 37 | 81 | 41 (50.6) | 40 (49.4) | |
≤ 37 | 17 | 8 (47.1) | 9 (52.9) | |
CD3 TILs | 0.96 | |||
High | 36 | 28 (77.8) | 8 (22.2) | |
Low | 59 | 47 (79.7) | 12 (20.3) | |
CD8 TILs | 0.26 | |||
High | 22 | 15 (68.2) | 7 (31.8) | |
Low | 73 | 60 (82.2) | 13 (17.8) | |
COX2 | 0.84 | |||
High | 48 | 38 (79.2) | 10 (20.8) | |
Low | 47 | 37 (78.7) | 10 (21.3) | |
Treatment group | 0.16 | |||
Celecoxib | 44 | 38 (86.4) | 6 (13.6) | |
Non-celecoxib | 51 | 37 (72.5) | 14 (27.5) |
Table 3 Univariate analysis of the correlation of clinicopathological parameters with overall survival in patients with colorectal carcinoma
HR | 95%CI | P value | |
Sex, male vs female | 0.750 | 0.399-1.411 | 0.37 |
Age in yr, ≤ 60 vs > 60 | 0.899 | 0.472-1.714 | 0.74 |
Cancer, colon vs rectum | 1.279 | 0.712-2.296 | 0.41 |
BMI, > 25 vs ≤ 25 | 1.579 | 0.697-3.579 | 0.21 |
Tumor differentiation, moderate and poor vs well | 2.798 | 1.373-5.702 | 0.039 |
Stage, 3 vs 2 | 1.003 | 0.534-1.882 | 0.99 |
T stage, T4 vs T2/3 | 1.418 | 0.755-2.664 | 0.27 |
N stage, N1/2 vs N0 | 1.005 | 0.536-1.887 | 0.99 |
CEA in ng/mL, > 5 vs ≤ 5 | 2.137 | 1.141-4.004 | 0.025 |
CA19-9 in U/mL, > 37 vs ≤ 37 | 1.262 | 0.547-2.911 | 0.56 |
CD3 TILs, high vs low | 1.195 | 0.649-2.198 | 0.55 |
CD8 TILs, high vs low | 2.096 | 0.975-4.504 | 0.018 |
Nuclear IDO1, high vs low | 2.044 | 0.871-4.798 | 0.039 |
Cytoplasmic IDO1, high vs low | 1.690 | 0.901-3.173 | 0.10 |
Nuclear and cytoplasmic IDO1, high vs low | 2.044 | 0.871-4.798 | 0.039 |
COX2, high vs low | 1.235 | 0.659-2.314 | 0.51 |
Nuclear IDO1/COX2, IV vs I/II/III | 3.048 | 0.868-10.7 | 0.0049 |
Cytoplasmic IDO1/COX2, IV vs I/II/III | 2.109 | 0.976-4.558 | 0.022 |
Treatment group, celecoxib vs non-celecoxib | 0.943 | 0.489-1.826 | 0.86 |
Table 4 Multivariate analysis of the correlation of indoleamine-2,3-dioxygenase 1 with overall survival in patients with Colorectal cancer
HR | 95%CI | P-value | |
Cytoplasmic IDO1 and COX2, IV vs I/II/III | 2.218 | 1.011-4.48 | 0.047 |
Tumor differentiation, poor and moderate vs well | 3.473 | 1.201-10.046 | 0.022 |
Table 5 Univariate analysis of the correlation of clinicopathological parameters with overall survival in CRC celecoxib subgroup
HR | 95%CI | P value | |
Sex, male vs female | 0.854 | 0.329-2.219 | 0.74 |
Age in yr, ≤ 60 vs > 60 | 1.249 | 0.432-3.609 | 0.70 |
Cancer, colon vs rectum | 1.034 | 0.420-2.543 | 0.94 |
BMI, > 25 vs ≤ 25 | 1.328 | 0.351-5.020 | 0.71 |
Tumor differentiation, moderate and poor vs well | 7.396 | 2.749-19.90 | 0.021 |
Stage, 3 vs 2 | 1.075 | 0.415-2.782 | 0.88 |
T stage, T4 vs T2/3 | 1.389 | 0.537-3.596 | 0.50 |
N stage, N1/2 vs N0 | 1.075 | 0.415-2.782 | 0.88 |
CEA in ng/mL, > 5 vs ≤ 5 | 1.934 | 0.743-5.033 | 0.21 |
CA19-9 in m/L, > 37 vs ≤ 37 | 1.551 | 0.431-5.575 | 0.43 |
CD3 TILs, high vs low | 1.02 | 0.414-2.510 | 0.97 |
CD8 TILs, high vs low | 2.821 | 0.774-10.29 | 0.026 |
Nuclear IDO1, high vs low | 3.023 | 0.585-15.61 | 0.041 |
Cytoplasmic IDO1, high vs low | 1.623 | 0.617-4.267 | 0.31 |
Nuclear and cytoplasmic IDO1, high vs low | 3.023 | 0.585-15.61 | 0.041 |
COX2, high vs low | 1.746 | 0.672-4.541 | 0.25 |
Nuclear IDO1/COX2, IV vs I/II/III | 1.885 | 0.279-12.76 | 0.38 |
Cytoplasmic IDO1/COX2, IV vs I/II/III | 2.740 | 0.764-9.831 | 0.038 |
Table 6 Multivariate analysis of the correlation of indoleamine-2,3-dioxygenase 1 with overall survival in Colorectal cancer celecoxib subgroup
HR | 95%CI | P-value | |
Cytoplasmic IDO1 and COX2, IV vs I/II/III | 3.210 | 1.074-9.590 | 0.037 |
Tumor differentiation, poor and moderate vs well | 11.962 | 1.526-23.787 | 0.018 |
- Citation: Ma WJ, Wang X, Yan WT, Zhou ZG, Pan ZZ, Chen G, Zhang RX. Indoleamine-2,3-dioxygenase 1/cyclooxygenase 2 expression prediction for adverse prognosis in colorectal cancer. World J Gastroenterol 2018; 24(20): 2181-2190
- URL: https://www.wjgnet.com/1007-9327/full/v24/i20/2181.htm
- DOI: https://dx.doi.org/10.3748/wjg.v24.i20.2181