Progesterone receptor membrane component 1 as a potential prognostic biomarker for hepatocellular carcinoma

Table 1 Prognostic significance of clinicopathological indicators, PGRMC1 and PGRMC2 for disease-free survival in the clinical cohort (n = 89)

Factor	DFS univariate				DFS multivariate
	Group	HR	95%CI	P value	HR	95%CI	P value
Age, yr	< 60/≥ 60	0.997	0.609-1.632	0.989
Sex	Male/female	1.014	0.599-1.715	0.960
Viral infection				0.825
	B/C	1.177	0.703-1.971
	B/B + C	1.068	0.448-2.547
Child-Pugh score	5/≥ 6	2.407	1.346-4.302	0.003a	2.005	(1.097-3.665)	0.024a
Cirrhosis	-/+	0.743	0.664-1.776	0.299
Serum AFP	< 100/≥ 100 ng/ml	1.357	0.823-2.238	0.231
Differentiation	W/M-P	1.682	0.943-2.999	0.078
Multifocal tumor	-/+	0.985	0.514-1.888	0.965
Satellite nodule	-/+	2.173	1.303-3.624	0.003a			NS
Tumor size	< 5/≥ 5 cm	2.446	1.486-4.028	< 0.001a			NS
Tumor capsular invasion	-/+	0.985	0.545-1.780	0.959
Vascular invasion	-/+	2.551	1.553-4.190	< 0.001a			NS
Liver capsule penetration	-/+	2.235	1.010-4.945	0.047a			NS
Bile duct invasion	-/+	3.200	0.986-10.385	0.053
Margin status, mm	≥ 1 /< 1	3.793	2.079-6.920	< 0.001a	4.720	(2.458-9.063)	< 0.001a
AJCC stage	I-II/ IIIA-C	2.907	1.738-4.861	< 0.001a	3.262	(1.895-5.617)	< 0.001a
PGRMC1	H/L	1.918	1.145-3.213	0.013a	2.384	(1.377-4.128)	0.002a
PGRMC2	H/L	1.377	0.798-2.379	0.251
ER	-/+	0.528	0.128-2.173	0.376
PR	-/+	0.777	0.243-2.484	0.670

^aP < 0.05. DFS: Disease-free survival; AFP: Alpha-fetoprotein; AJCC: American Joint Committee on Cancer; H: High expression; L: Low expression.

Table 2 Prognostic significance of clinicopathological indicators, progesterone receptor membrane component 1 and PGRMC2 for disease-free survival in The Cancer Genome Atlas cohort (n = 373)

Factor	DFS univariate				DFS multivariate
	Group	HR	95%CI	P value	HR	95%CI	P value
Age, yr	< 60/≥ 60	1.019	0.756-1.373	0.903
Sex	Male/female	1.157	0.845-1.585	0.364
HCC risk factors				0.014a			< 0.001a
	B/NAFLD	1.433	0.601-3.414	0.417	2.903	(1.130-7.461)	0.027a
	B/Alcohol	1.449	0.948-2.217	0.087	1.002	(0.595-1.689)	0.993
	B/C	2.421	1.422-4.121	0.001a	3.368	(1.773-6.395)	< 0.001a
Child-Pugh score	A/B-C	1.332	0.709-2.504	0.372
Cirrhosis	-/+	1.117	0.761-1.641	0.572
Serum AFP, ng/ml	< 100/≥ 100	1.097	0.752-1.599	0.632
Tumor grade	2/4/2001	1.330	0.868-2.038	0.191
Vascular invasion	-/+	2.001	1.418-2.823	< 0.001a	3.040	(1.889-4.891)	< 0.001a
Residual tumor	-/+	1.733	0.938-3.200	0.079
AJCC stage	I-II/III -IV	2.354	1.693-3.272	< 0.001a	1.899	(1.107-3.255)	0.020a
PGRMC1	H/L	1.834	1.359-2.475	< 0.001a	2.857	(1.781-4.584)	< 0.001a
PGRMC2	H/L	1.242	0.923-1.671	0.152

^aP < 0.05. DFS: Disease-free survival; NAFLD: Non-alcoholic fatty liver disease; AFP: Alpha-fetoprotein; AJCC: American Joint Committee on Cancer; H: High expression; L: Low expression.