Improved experimental model of hepatic cystic hydatid disease resembling natural infection route with stable growing dynamics and immune reaction

Table 1 Hydatid disease infection rate in mice in the three groups injected with different concentrations of protoscolices

Group	Concentration of injected protoscolices	Number of infected mice	Number of non-infected mice	Total	Infection rate (%)a
Group A	2000/100 μL	9	1	10	90.0
Group B	200/100 μL	10	0	10	100.0
Group C	100/100 μL	7	4	11	63.6
Total		26	5	31	84.55

^aP = 0.096, no significant difference in the infection rates among the three groups.

Table 2 Lobe position and quantity of hydatid cysts in the mouse liver

Mouse ID	Group A	Group B	Group C
1	Middle lobe: 2	Middle lobe: 2	Right lobe: 3
	Upper right lobe: 1	Lower right lobe: 2	Lateral left lobe: 1
	Lower right lobe: 1	Lateral left lobe: 3
2	Middle lobe: 6	Middle lobe: 1	Lateral left lobe: 2
	Upper right lobe: 5	Lateral left lobe: 1
3	Multiple cysts all over the liver	Lower right lobe: 1	None
4	Middle lobe: 6	Upper right lobe: 2	Middle lobe: 3
	Upper right lobe: 2		Lateral left lobe: 3
	Lower right lobe: 2
	Lateral left lobe: 2
5	Multiple cysts all over the liver	Middle lobe: 3	Lower right lobe: 1
		Upper right lobe: 1	Lateral left lobe: 3
6	None	Lower right lobe: 1	None
7	Multiple cysts all over the liver	Upper right lobe: 1	Middle lobe: 1
8	Middle lobe: 1	Lateral left lobe: 4	Middle lobe: 2
	Upper lobe: 1		Lateral left lobe: 3
9	Multiple cysts all over the liver	Lateral left lobe: 1	Middle lobe: 1
10	Multiple cysts all over the liver	Upper right lobe: 1	None
		Lower right lobe: 2
11	-	-	None

Table 3 Diameter of the hepatic cystic echinococcosis lesion over time

	Week 24	Week 28	Week 29	Week 32	Week 36	P
Cyst diameter (mm)	2.48 ± 0.91	3.29 ± 1.86	3.87 ± 2.26	5.00 ± 2.57	7.98 ± 2.75	0.001

Data shown are mean ± SD.