Prediction of esophageal and gastric histology by macroscopic diagnosis during upper endoscopy in pediatric celiac disease

Table 1 Characteristics of pediatric celiac disease patients reviewed for study inclusion at the time of upper endoscopy and biopsy (n = 140) n (%)

	Result
Demographics
Female gender	86/140 (61.4)
Age at biopsy (yr) (mean ± SD)	9.1 ± 4.3
Weight at biopsy (kg) (mean ± SD)	34.7 ± 18.9
Height at biopsy (cm) (mean ± SD)	134.4 ± 25.1
Presenting symptoms
Abdominal pain	87/140 (62.1)
Constipation	41/140 (29.3)
Bloating	40/140 (28.6)
Fatigue	37/140 (26.4)
Irritability	36/140 (25.7)
Poor weight gain	35/140 (25.0)
Diarrhea	33/140 (23.6)
Vomiting	13/140 (9.3)
Asymptomatic	14/140 (10.0)
Serology
aTTG (n = 137) (mean ± SD)	393.9 ± 634.1 (0.9-3550)
IgA (n = 75) (mean ± SD)	1.3 ± 0.7 (0.1-3.1)

aTTG: Anti-tissue transglutaminase; IgA: Immunoglobulin A.

Table 2 Macroscopic and histologic findings in the esophagus of pediatric patients undergoing upper endoscopy for investigation of celiac disease n (%)

Diagnosis	Endoscopic	Histologic
Normal	57/76 (75.0)	58/76 (76.3)
Eosinophilic esophagitis	9/76 (11.8)	8/76 (10.5)
Reflux esophagitis	6/76 (7.9)	8/76 (10.5)
Glycogenic acanthosis	1/76 (1.3)	1/76 (1.3)
Non-specific abnormalities	3/76 (3.9)	1/76 (1.3)

Table 3 Macroscopic and histologic findings in the stomach of pediatric patients undergoing upper endoscopy for investigation of celiac disease n (%)

Diagnosis	Endoscopic	Histologic
Normal	94/109 (86.2)	95/109 (87.2)
Gastritis	9/109 (8.3)	14/109 (12.8)
Pancreatic rest	1/109 (0.9)	-
Non-specific abnormalities	5/109 (4.6)	-